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aggrecan

Overview page. Subjects: Medicine and Health — Chemistry.

The major structural proteoglycan of cartilage, the core protein (2316 aa) to which ~100 chondroitin sulphate chains and several keratan sulphate chains as well as O- and N-linked...

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aggrecan

Overview page. Subjects: Medicine and Health — Chemistry.

The major structural proteoglycan of cartilage, the core protein (2316 aa) to which ~100 chondroitin sulphate chains and several keratan sulphate chains as well as O- and N-linked...

See overview in Oxford Index

aggrecan

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 89 words.

The major structural *proteoglycan of cartilage, the core protein (2316 aa) to which ~100 chondroitin sulphate chains and several

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aggrecan

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 40 words.

the major proteoglycan of cartilage. It has approximately one glycosaminoglycan chain for every 20 amino‐acid residues, and a total mass

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Aggrecan-Associated Skeletal Dysplasias (MIM 608361, 612813)

Jürgen W. Spranger, Paula W. Brill, Gen Nishimura, Andrea Superti-Furga and Sheila Unger.

in Bone Dysplasias

September 2012; p ublished online November 2013 .

Chapter. Subjects: Clinical Genetics; Clinical Radiology. 857 words.

Chapter 29 covers Aggrecan-associated skeletal dysplasias (MIM 608361, 612813), including major clinical findings, radiographic features, and differential diagnoses.

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CD44 binds a chondroitin sulfate proteoglycan, aggrecan

Takashi Fujimoto, Hiroto Kawashima, Toshiyuki Tanaka, Mayumi Hirose, Noriko Toyama-Sorimachi, Yuji Matsuzawa and Masayuki Miyasaka.

in International Immunology

March 2001; p ublished online March 2001 .

Journal Article. Subjects: Immunology; Biological Sciences. 6527 words.

Here we report that CD44 binds a chondroitin sulfate (CS) proteoglycan, aggrecan, a major component of cartilage. Soluble CD44–IgG and CD44+ cells bound to aggrecan from rat chondrosarcoma...

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A candidate enhancer element responsible for high-level expression of the aggrecan gene in chondrocytes

Yuichi Ikeda, Kazuo Ito, Yuichi Izumi and Tamayuki Shinomura.

in The Journal of Biochemistry

July 2014; p ublished online February 2014 .

Journal Article. Subjects: Biochemistry. 4768 words.

Aggrecan is the most abundant proteoglycan in cartilage. It contains a lot of negatively charged glycosaminoglycan chains along the core protein, providing a large osmotic swelling pressure...

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The Development and Activity-Dependent Expression of Aggrecan in the Cat Visual Cortex

P. C. Kind, F. Sengpiel, C. J. Beaver, A. Crocker-Buque, G. M. Kelly, R. T. Matthews and D. E. Mitchell.

in Cerebral Cortex

February 2013; p ublished online February 2012 .

Journal Article. Subjects: Neuroscience. 10228 words.

The Cat-301 monoclonal antibody identifies aggrecan, a chondroitin sulfate proteoglycan in the cat visual cortex and dorsal lateral geniculate nucleus (dLGN). During development, aggrecan...

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Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy

A. N. Corps, A. H. N. Robinson, T. Movin, M. L. Costa, B. L. Hazleman and G. P. Riley.

in Rheumatology

March 2006; p ublished online October 2005 .

Journal Article. Subjects: Rheumatology. 2651 words.

Objectives. To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles...

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Roles of Aggrecan, a Large Chondroitin Sulfate Proteoglycan, in Cartilage Structure and Function

Hideto Watanabe, Yoshihiko Yamada and Koji Kimata.

in The Journal of Biochemistry

October 1998; p ublished online October 1998 .

Journal Article. Subjects: Biochemistry. 0 words.

Aggrecan, a large aggregating proteoglycan, is one of the major structural components of cartilage. Its core protein contains three glubular domains and two glycosaminoglycan-attachment...

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The G1 domain of aggrecan released from porcine articular cartilage forms stable complexes with hyaluronan/link protein

T. Yasumoto, J. L. E. Bird, K. Sugimoto, R. M. Mason and M. T. Bayliss.

in Rheumatology

February 2003; p ublished online February 2003 .

Journal Article. Subjects: Rheumatology. 4446 words.

Objective. To raise peptide antibodies recognizing the C‐terminal amino acid sequence in the G1 domain of porcine aggrecan, generated by the action of either aggrecanase or...

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SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer

Miriam Aza-Carmona, Debbie J. Shears, Patricia Yuste-Checa, Verónica Barca-Tierno, Alfonso Hisado-Oliva, Alberta Belinchón, Sara Benito-Sanz, J. Ignacio Rodríguez, Jesús Argente, Ángel Campos-Barros, Peter J. Scambler and Karen E. Heath.

in Human Molecular Genetics

April 2011; p ublished online January 2011 .

Journal Article. Subjects: Genetics and Genomics. 7242 words.

SHOX (short stature homeobox-containing gene) encodes a transcription factor implicated in skeletal development. SHOX haploinsufficiency has been demonstrated in Leri–Weill...

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Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis

J. Zou, Y. Zhang, A. Thiel, M. Rudwaleit, S.‐L. Shi, A. Radbruch, R. Poole, J. Braun and J. Sieper.

in Rheumatology

July 2003; p ublished online July 2003 .

Journal Article. Subjects: Rheumatology. 7180 words.

Objectives. Based on their HLA association, both ankylosing spondylitis (AS) and rheumatoid arthritis (RA) seem to be T‐cell‐driven diseases in which the autoantigens remain to...

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G1-G2 Aggrecan Product that can be Generated by M-calpain on Truncation at Ala<sup>709</sup>–Ala<sup>710</sup> is Present Abundantly in Human Articular Cartilage

Hideaki Maehara, Kiichi Suzuki, Tomohiro Sasaki, Hidefumi Oshita, Eriko Wada, Toshiyuki Inoue and Katsuji Shimizu.

in The Journal of Biochemistry

April 2007; p ublished online January 2007 .

Journal Article. Subjects: Biochemistry. 4933 words.

To elucidate the specific function of m-calpain in the metabolism of aggrecan in human articular cartilage, the prevalence and localization of a large glycosaminoglycan-bearing aggrecan...

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Down-regulated <i>HS6ST2</i> in osteoarthritis and Kashin–Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes

Wei Wang, Bo Zhong, Jian Sun, Junling Cao, Juan Tian, Nannan Zhong, Wenxiang Zhao, Lifang Tian, Peng Xu, Dawei Guo, Xichi Ju, Wei Ma, Meng Li, Weikun Hou and Shemin Lu.

in Rheumatology

December 2011; p ublished online October 2011 .

Journal Article. Subjects: Rheumatology. 5169 words.

Objective. Primary OA and Kashin–Beck disease (KBD) show similar pathological changes in articular cartilage. The objective was to screen differentially expressed genes between...

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lecticans

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 30 words.

A family of chondroitin sulphate proteoglycans that includes *aggrecan, *versican, neurocan, and brevican. They have a

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lecticans

Overview page. Subjects: Medicine and Health.

A family of chondroitin sulphate proteoglycans that includes aggrecan, versican, neurocan, and brevican. They have a hyaluronan-binding and C-type lectin domains and act as crosslinkers in...

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Identification of Aggrecanase Activity in Medium of Cartilage Culture

Kotaro Sugimoto, Masaaki Takahashi, Yumiko Yamamoto, Eohei Shimada and Kazuhiko Tanzawa.

in The Journal of Biochemistry

August 1999; p ublished online August 1999 .

Journal Article. Subjects: Biochemistry. 0 words.

Erosion of cartilage is a major feature of joint diseases, i.e., osteoarthritis and rheumatoid arthritis, which leads with time to a loss of joint function. Proteolytic cleavage of the...

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Tumour necrosis factor <i>α</i> stimulates nitric oxide production more potently than interleukin‐1<i>β</i> in porcine articular chondrocytes

N. J. Goodstone and T. E. Hardingham.

in Rheumatology

August 2002; p ublished online August 2002 .

Journal Article. Subjects: Rheumatology. 5079 words.

Objective. To compare the time‐ and concentration‐dependent effects of tumour necrosis factor α (TNF‐α) and interleukin 1β (IL‐1β) on the induction of nitric oxide synthase...

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Changes with Age and the Effect of Recombinant Human BMP-2 on Proteoglycan and Collagen Gene Expression in Rabbit Anulus Fibrosus Cells

Qin-Ming Fei, Xiao-Xing Jiang, Tong-Yi Chen, Jun Li, Hideki Murakami, Kai-Jow Tsai and William C. Hutton.

Edited by Ming-Hua Xu.

in Acta Biochimica et Biophysica Sinica

November 2006; p ublished online November 2006 .

Journal Article. Subjects: Biochemistry. 0 words.

In order to compare the difference between young and old intervertebral disc cells and their responsiveness to recombinant human bone morphogenetic protein-2 (rhBMP-2), disc cells were...

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Chondrodysplasias due to proteoglycan defects

Nancy B. Schwartz and Miriam Domowicz.

in Glycobiology

April 2002; p ublished online April 2002 .

Journal Article. Subjects: Carbohydrates. 9923 words.

The proteoglycans, especially the large chondroitin sulfate proteoglycan aggrecan, have long been viewed as important components of the extracellular matrix of cartilage. The drastic change...

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