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arginase

Overview page. Subjects: Chemistry.

abbr. (in clinical biochemistry): ARS; recommended name for EC 3.5.3.1; other names: arginine amidinase; systematic name: L‐arginine amidinohydrolase. An enzyme that catalyses...

See overview in Oxford Index

arginase

Overview page. Subjects: Chemistry.

abbr. (in clinical biochemistry): ARS; recommended name for EC 3.5.3.1; other names: arginine amidinase; systematic name: L‐arginine amidinohydrolase. An enzyme that catalyses...

See overview in Oxford Index

arginase

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 137 words.

abbr. (in clinical biochemistry): ARS; recommended name for EC 3.5.3.1; other names: arginine amidinase; systematic name: L‐arginine

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Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats

Isabel Rodríguez-Gómez, Juan Manuel Moreno, Rosario Jimenez, Andrés Quesada, Sebastian Montoro-Molina, Pablo Vargas-Tendero, Rosemary Wangensteen and Félix Vargas.

in American Journal of Hypertension

December 2015; p ublished online April 2015 .

Journal Article. Subjects: Cardiovascular Medicine; Biological Sciences. 5084 words.

BACKGROUND

This study analyzed the effects of chronic administration of N[omega]-hydroxy-nor-l-arginine (nor-NOHA), an inhibitor of arginase, on the...

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Arginase inhibition mediates cardioprotection during ischaemia–reperfusion

Christian Jung, Adrian T. Gonon, Per-Ove Sjöquist, Jon O. Lundberg and John Pernow.

in Cardiovascular Research

January 2010; p ublished online September 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4326 words.

Aims

Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection against ischaemic heart disease. Arginase is up-regulated...

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Arginase-1 expression in granulomas of tuberculosis patients

Ana P. Pessanha, Rodrigo A.P. Martins, Ana L. Mattos-Guaraldi, Albanita Vianna and Lilian O. Moreira.

in FEMS Immunology & Medical Microbiology

November 2012; p ublished online October 2012 .

Journal Article. Subjects: Medical Microbiology and Virology; Biotechnology; Genetics and Genomics; Microbiology; Molecular and Cell Biology. 2140 words.

Abstract

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen able to survive and multiply within macrophages. Several mechanisms allow...

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Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia

Sowndramalingam Sankaralingam, Han Xu and Sandra T. Davidge.

in Cardiovascular Research

January 2010; p ublished online August 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 5493 words.

Aims

Preeclampsia is a hypertensive disorder characterized by vascular oxidative stress. Decreased availability of the vasodilator nitric oxide (NO) has...

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Involvement of arginase in regulating myometrial contractions during gestation in the rat

Misako Hirata, Satoshi Obayashi, Shuichi Sakamoto, Takeshi Aso, Masatoshi Imamura and Hiroshi Azuma.

in MHR: Basic science of reproductive medicine

August 2006; p ublished online May 2006 .

Journal Article. Subjects: Reproductive Medicine. 5114 words.

This study was designed to investigate the role of arginase in regulating myometrial contractions during gestation in the rat. Arginase activity in the myometrium was significantly...

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Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A. Toque, Jijun Chen, Reem T. Atawia, Abdelrahman Y. Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B. Caldwell and Robert W. Caldwell.

in Cardiovascular Research

November 2017; p ublished online September 2017 .

Journal Article. Subjects: Cardiovascular Medicine. 8253 words.

Abstract

Aims

Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension...

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Expression of Arginase II and Related Enzymes in the Rat Small Intestine and Kidney

Mikiko Ozaki, Tomomi Gotoh, Akitoshi Nagasaki, Kei Miyanaka, Motohiro Takeya, Shigetoshi Fujiyama, Kimio Tomita and Masataka Mori.

in The Journal of Biochemistry

March 1999; p ublished online March 1999 .

Journal Article. Subjects: Biochemistry. 0 words.

Arginase, which catalyzes the conversion of arginine to urea and omithine, and consists of a liver-type (arginase I) and a non-hepatic type (arginase II). Arginine is also used for the...

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Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

John Pernow and Christian Jung.

in Cardiovascular Research

June 2013; p ublished online February 2013 .

Journal Article. Subjects: Cardiovascular Medicine. 6495 words.

Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric...

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Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

Teddy Bagnost, Ling Ma, Rafaela F. da Silva, Rana Rezakhaniha, Christophe Houdayer, Nikos Stergiopulos, Claire André, Yves Guillaume, Alain Berthelot and Céline Demougeot.

in Cardiovascular Research

August 2010; p ublished online March 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 4974 words.

Aims

Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we...

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Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Lin Yao, Surabhi Chandra, Haroldo A. Toque, Anil Bhatta, Modesto Rojas, Ruth B. Caldwell and R. William Caldwell.

in Cardiovascular Research

March 2013; p ublished online December 2012 .

Journal Article. Subjects: Cardiovascular Medicine. 5151 words.

Aims

We determined the role of the Rho kinase (ROCK) isoforms in diabetes-induced vascular endothelial dysfunction and enhancement of arginase activity and...

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Increased Level of Arginase Activity Correlates with Disease Severity in HIV-Seropositive Patients

T. E. Cloke, L. Garvey, B.-S. Choi, T. Abebe, A. Hailu, M. Hancock, U. Kadolsky, C. R. M. Bangham, M. Munder, I. Müller, G. P. Taylor and P. Kropf.

in The Journal of Infectious Diseases

August 2010; p ublished online August 2010 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 5944 words.

Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4+ T cells is frequently used to...

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Inducible Nitric Oxide Synthase and Arginase Expression in Heart Tissue during Acute <i>Trypanosoma cruzi</i> Infection in Mice: Arginase I Is Expressed in Infiltrating CD68<sup>+</sup> Macrophages

Henar Cuervo, Miguel A. Pineda, M. Pilar Aoki, Susana Gea, Manuel Fresno and Núria Gironès.

in The Journal of Infectious Diseases

June 2008; p ublished online June 2008 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 6314 words.

In Chagas disease, which is caused by Trypanosoma cruzi, macrophages and cardiomyocytes are the main targets of infection. Classical activation of macrophages during infection is...

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Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation

Xu-Ping Wang, Wei Zhang, Xiao-Qian Liu, Wen-Ke Wang, Fei Yan, Wen-Qian Dong, Yun Zhang and Ming-Xiang Zhang.

in European Heart Journal

April 2014; p ublished online September 2013 .

Journal Article. Subjects: Cardiovascular Medicine. 4127 words.

Aims

The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its...

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P183Arginase inhibition protecs from ischemia-reperfusion injury in patients with coronary artery disease

O Kovamees, A Shemyakin and J Pernow.

in Cardiovascular Research

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Background: Arginase is an important regulator of nitric oxide production by competing with nitric oxide synthase for their common substrate L-arginine. Up-regulation of...

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PM-16IMMUNOSUPPRESSIVE FACTORS, MDSC AND ARGINASE, ARE ELEVATED IN DOGS WITH MALIGNANT GLIOMA

Liz Pluhar, Michelle Goulart, Charles Seiler and Michael Olin.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Immunotherapy for malignant gliomas has striking efficacy in rodent models but very limited effects in clinical trials, which may reflect immunological differences between induced and...

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<span class="smallCaps">d</span>-Arginase of <i>Arthrobacter</i> sp. KUJ 8602: Characterization and Its Identity with Zn<sup>2+</sup>-Guanidinobutyrase

Noriaki Arakawa, Motoki Igarashi, Takayuki Kazuoka, Tadao Oikawa and Kenji Soda.

in The Journal of Biochemistry

January 2003; p ublished online January 2003 .

Journal Article. Subjects: Biochemistry. 6949 words.

d-Arginase activity was found in the cells of an isolate, Arthrobacter sp. KUJ 8602, grown in the l-arginine medium, and the enzyme was purified and characterized. Its...

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Arginase I, Polyamine, and Prostaglandin E<sub>2</sub> Pathways Suppress the Inflammatory Response and Contribute to Diffuse Cutaneous Leishmaniasis

Jaqueline França-Costa, Johan Van Weyenbergh, Viviane S. Boaventura, Nívea F. Luz, Hayna Malta-Santos, Murilo Cezar Souza Oliveira, Daniela Conceição Santos de Campos, Ana Cristina Saldanha, Washington L. C. dos-Santos, Patrícia T. Bozza, Manoel Barral-Netto, Aldina Barral, Jackson M. Costa and Valeria M. Borges.

in The Journal of Infectious Diseases

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 5199 words.

Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of tegumentary leishmaniasis. The molecular mechanisms underlying DCL pathogenesis remain unclear, and there is no...

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P419Involvement of arginase and Rho kinase in the cardioprotecive effect of remote ischemic perconditioning in vivo

A Kiss, Y Tratsiakovich, AT Gonon and J Pernow.

in Cardiovascular Research

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Aims: It is well established that remote ischemic perconditioning (RIPerc) effectively protects from myocardial ischemia-reperfusion (IR) injury. The signaling events...

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