Oxidative DNA damage in human lymphocytes: correlations with plasma levels of α-tocopherol and carotenoids
February 2000; p ublished online February 2000 .
Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3215 words.
In order to investigate whether oxidative damage is associated with differences in antioxidant intake, we measured the levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) in...
The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats
May 2000; p ublished online May 2000 .
Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3787 words.
As we have shown previously [Tardieu,D., Jaeg,J.P., Cadet,J., Embvani,E., Corpet,D.E. and Petit,C. (1998) Cancer Lett, 134, 1–5], a 48-h treatment of 6% dextran sodium sulphate (DSS) in...
Cellular background level of 8-oxo-7,8-dihydro-2′-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up
November 2002; p ublished online November 2002 .
Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 8205 words.
The measurement of oxidative damage to cellular DNA is a challenging analytical problem requiring highly sensitive and specific methods. In addition, artefactual DNA oxidation during its...
Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells
in DNA Research
October 2015; p ublished online August 2015 .
Journal Article. Subjects: Genetics and Genomics. 7799 words.
Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression...
in FEMS Microbiology Ecology
August 2010; p ublished online June 2010 .
Journal Article. 4339 words.
The objective of this study was to investigate the photobiological responses of the haloalkaliphilic euryarchaeon Natronomonas pharaonis to environmentally relevant polychromatic UV...
Comprehensive functional annotation of 18 missense mutations found in suspected hemochromatosis type 4 patients
in Human Molecular Genetics
September 2014; p ublished online April 2014 .
Journal Article. Subjects: Genetics and Genomics. 6222 words.
Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (null...
in Human Molecular Genetics
September 2003; p ublished online September 2003 .
Journal Article. Subjects: Genetics and Genomics. 4502 words.
Haemochromatosis (HH) is a clinically and genetically heterogeneous disease caused by inappropriate iron absorption. Most HH patients are homozygous for the C282Y mutation in the HFE gene....
Implications of Plasma Δ9-Tetrahydrocannabinol, 11-Hydroxy-THC, and 11-nor-9-Carboxy-THC Concentrations in Chronic Cannabis Smokers
in Journal of Analytical Toxicology
October 2009; p ublished online October 2009 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.
Δ9-Tetrahydrocannabinol (THC) is commonly found in toxicological specimens from driving under the influence and accident investigations. Plasma cannabinoid concentrations were determined in...
Relationship between medication event rates and the Leapfrog computerized physician order entry evaluation tool
in Journal of the American Medical Informatics Association
June 2013; p ublished online April 2013 .
Journal Article. Subjects: Medical Statistics and Methodology; Bioinformatics and Computational Biology; Biomathematics and Statistics. 4640 words.
Objective The Leapfrog CPOE evaluation tool has been promoted as a means of monitoring computerized physician order entry (CPOE). We...
Oxidative damage and induced mutations in M13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA radiation
November 2000; p ublished online November 2000 .
Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 3590 words.
N-Nitrosopyrrolidine (NPYR) is carcinogenic in rodents and undergoes α-hydroxylation upon microsomal CYP450 metabolism, giving rise to mutations. Previously, we reported the...