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A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863

A. P. Venook, C. Enders Klein, G. Fleming, D. Hollis, C. G. Leichman, R. Hohl, J. Byrd, D. Budman, M. Villalona, J. Marshall, G. L. Rosner, J. Ramirez, H. Kastrissios and M. J. Ratain.

in Annals of Oncology

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Medical Oncology. 4610 words.


To ascertain if hepatic or renal dysfunction or prior pelvic radiation (XRT) leads to increased toxicity at a given dose of irinotecan and to...

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Reducing the search space for causal genetic variants with VASP

Matthew A. Field, Vicky Cho, Matthew C. Cook, Anselm Enders, Carola G. Vinuesa, Belinda Whittle, T. Daniel Andrews and Chris C. Goodnow.

in Bioinformatics

July 2015; p ublished online March 2015 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 1480 words.

Motivation: Increasingly, cost-effective high-throughput DNA sequencing technologies are being utilized to sequence human pedigrees to elucidate the genetic cause of a wide...

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Reconstructing Disturbances and Their Biogeochemical Consequences over Multiple Timescales

Kendra K. McLauchlan, Philip E. Higuera, Daniel G. Gavin, Steven S. Perakis, Michelle C. Mack, Heather Alexander, John Battles, Franco Biondi, Brian Buma, Daniele Colombaroli, Sara K. Enders, Daniel R. Engstrom, Feng Sheng Hu, Jennifer R. Marlon, John Marshall, Matt McGlone, Jesse L. Morris, Lucas E. Nave, Bryan Shuman, Erica A. H. Smithwick, Dunia H. Urrego, David A. Wardle, Christopher J. Williams and Joseph J. Williams.

in BioScience

February 2014; p ublished online January 2014 .

Journal Article. 7208 words.

Ongoing changes in disturbance regimes are predicted to cause acute changes in ecosystem structure and function in the coming decades, but many aspects of these predictions are uncertain. A...

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The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat.

U Enders, R Lobb, R B Pepinsky, H P Hartung, K V Toyka and R Gold.

in Brain

July 1998; p ublished online July 1998 .

Journal Article. Subjects: Neurology; Neuroscience. 0 words.

We have investigated the functional role of very late antigen-4 [VLA-4 (alpha4/beta1) integrin] and vascular cell adhesion molecule-1 (VCAM-1) in experimental autoimmune neuritis (EAN), an...

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Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets

Ruisheng Yao, Yian Wang, Yan Lu, William J. Lemon, David W. End, Clinton J. Grubbs, Ronald A. Lubet and Ming You.

in Carcinogenesis

July 2006; p ublished online January 2006 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 7654 words.

Rats treated with the alkylating agent methylnitrosourea (MNU) develop multiple, hormonally dependent mammary tumors. Roughly 50% of the tumors have Ha-ras mutation, whereas 50% do not. The...

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Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

Wing Pui Tsang, Enders K.O. Ng, Simon S.M. Ng, Hongchuan Jin, Jun Yu, Joseph J.Y. Sung and Tim Tak Kwok.

in Carcinogenesis

March 2010; p ublished online November 2009 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5113 words.

H19 is an imprinted oncofetal non-coding RNA recently shown to be the precursor of miR-675. The pathophysiological roles of H19 and its mature product miR-675 to carcinogenesis have,...

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NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors

Vivian Y. Shin, Hongchuan Jin, Enders K.O. Ng, Alfred S.L. Cheng, Wilson W.S. Chong, Christine Y.P. Wong, Wai K. Leung, Joseph J.Y. Sung and Kent-Man Chu.

in Carcinogenesis

February 2011; p ublished online November 2010 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 4114 words.

Cigarette smoke is one of the risk factors for gastric cancer and nicotine has been reported to promote tumor growth. Deregulation of microRNA (miRNA) and cyclooxygenase-2 (COX-2)...

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Genome-wide CpG island methylation analyses in non-small cell lung cancer patients

Gerwin Heller, Valerie N. Babinsky, Barbara Ziegler, Marlene Weinzierl, Christian Noll, Corinna Altenberger, Leonhard Müllauer, Gerhard Dekan, Yuliya Grin, György Lang, Adelheid End-Pfützenreuter, Irene Steiner, Sonja Zehetmayer, Balazs Döme, Britt-Madeleine Arns, Kwun M. Fong, Casey M. Wright, Ian A. Yang, Walter Klepetko, Martin Posch, Christoph C. Zielinski and Sabine Zöchbauer-Müller.

in Carcinogenesis

March 2013; p ublished online November 2012 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5901 words.

DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands in tumors...

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Life-Threatening Parvovirus B19-Associated Myocarditis and Cardiac Transplantation as Possible Therapy: Two Case Reports

G. Enders, J. Dötsch, J. Bauer, W. Nützenadel, H. Hengel, D. Haffner, G. Schalasta, K. Searle and K. E. Brown.

in Clinical Infectious Diseases

February 1998; p ublished online February 1998 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 0 words.

Parvovirus B19 infection can cause a wide spectrum of disease syndromes. Two cases of parvovirus B19 infection were identified that resulted in life-threatening myocarditis shortly after...

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Soybean Aphid (Hemiptera: Aphididae) Response to Soybean Plant Defense: Stress Levels, Tradeoffs, and Cross-Virulence

Laramy Enders, Ryan Bickel, Jennifer Brisson, Tiffany Heng-Moss, Blair Siegfried, Anthony Zera and Nick Miller.

in Environmental Entomology

February 2014; p ublished online December 2014 .

Journal Article. 7839 words.

A variety of management methods to control the soybean aphid (Aphis glycines Matsumura) have been investigated since its invasion into North America in 2000, among them plant resistance has...

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