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geranylgeranyl

Overview page. Subjects: Chemistry.

The (2E,6E,10E)‐3,7,11,15‐tetramethyl‐2,6,10,14‐hexadecatetraen‐1‐yl group. The 1‐diphosphate derivative is a substrate for enzymes introducing the geranylgeranyl group into proteins. See...

See overview in Oxford Index

geranylgeranyl

Overview page. Subjects: Chemistry.

The (2E,6E,10E)‐3,7,11,15‐tetramethyl‐2,6,10,14‐hexadecatetraen‐1‐yl group. The 1‐diphosphate derivative is a substrate for enzymes introducing the geranylgeranyl group into proteins. See...

See overview in Oxford Index

geranylgeranyl

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 21 words.

the (2E,6E,10E)‐3,7,11,15‐tetramethyl‐2,6,10,14‐hexadecatetraen‐1‐yl group. The 1‐diphosphate derivative is a substrate for enzymes introducing the geranylgeranyl

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Human Geranylgeranyl Diphosphate Synthase is an Octamer in Solution

Yukino Miyagi, Yoshihiro Matsumura and Hiroshi Sagami.

in The Journal of Biochemistry

September 2007; p ublished online July 2007 .

Journal Article. Subjects: Biochemistry. 2711 words.

A recombinant geranylgeranyl diphosphate synthase (GGPS) was analysed to be a mixture of octamer, hexamer and dimer by gel filtration using a Superdex 200 column followed by the blue native...

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Identification and Characterization of Geranylgeraniol Kinase and Geranylgeranyl Phosphate Kinase from the Archaebacterium <i>Sulfolobus acidocaldariu</i>

Shin-ichi Ohnuma, Masatada Watanabe and Tokuzo Nishino.

in The Journal of Biochemistry

March 1996; p ublished online March 1996 .

Journal Article. Subjects: Biochemistry. 0 words.

Geranylgeranyl diphosphate is an important precursor of archaebacterial ether-linked lipids, and it has been thought that all of this compound is “de novo” synthesized by geranylgeranyl...

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Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in <i>Arabidopsis</i>

Malgorzata Gutkowska, Marta Wnuk, Julita Nowakowska, Malgorzata Lichocka, Michal M. Stronkowski and Ewa Swiezewska.

in Journal of Experimental Botany

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Plant Sciences and Forestry. 7608 words.

Rab proteins, key players in vesicular transport in all eukaryotic cells, are post-translationally modified by lipid moieties. Two geranylgeranyl groups are attached to the Rab protein by...

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Partial Characterization of Farnesyl and Geranylgeranyl Diphosphatases Induced in Rice Seedlings by UV-C Irradiation

Jaehyuk Nah, Seon-Joo Song and Kyoungwhan Back.

in Plant and Cell Physiology

August 2001; p ublished online August 2001 .

Journal Article. Subjects: Biochemistry; Molecular and Cell Biology; Plant Sciences and Forestry. 2534 words.

This study reports the identification and characterization of allyl diphosphatases (EC 3.1.7.1) in plants by using rice seedlings. Two distinct Mg2+-independent allyl diphosphatases, which...

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Homology modeling of Neurospora crassa geranylgeranyl pyrophosphate synthase: structural interpretation of mutant phenotypes.

M Quondam, C Barbato, A Pickford, M Helmer-Citterich and G Macino.

in Protein Engineering, Design and Selection

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Proteins. 0 words.

A model of the tertiary structure of the Neurospora crassa carotenogenic prenyltransferase, geranylgeranyl pyrophosphate synthase (GGPPS), is presented, based on structural homology with...

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geranylgeranyl pyrophosphate synthetase

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 5 words.

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Recognition of Allylic Substrates in <i>Sulfolobus acidocaldarius</i> Geranylgeranyl Diphosphate Synthase: Analysis Using Mutated Enzymes and Artificial Allylic Substrates

Shin-ichi Ohnuma, Hisashi Hemmi, Tanetoshi Koyama, Kyozo Ogura and Tokuzo Nishino.

in The Journal of Biochemistry

June 1998; p ublished online June 1998 .

Journal Article. Subjects: Biochemistry. 0 words.

We examined the substrate specificity of two mutated geranylgeranyl diphosphate synthases, I-9 and I-11, with respect to several artificial substrates. These mutated enzymes have...

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Cloning and Functional Expression of a Novel Geranylgeranyl Pyrophosphate Synthase Gene from <i>Arabidopsis thaliana</i> in <i>Escherichia coli</i>

Fen Zhu, Kengo Suzuki, Kazunori Okada, Katsunori Tanaka, Tsuyoshi Nakagawa, Makoto Kawamukai and Hideyuki Matsuda.

in Plant and Cell Physiology

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Biochemistry; Molecular and Cell Biology; Plant Sciences and Forestry. 0 words.

A gene encoding a novel geranylgeranyl pyrophosphate (GGPP) synthase from Arabidopsis thaliana has been identified and termed GGPS5. The gene has been sequenced and expressed in Escherichia...

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Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart

Zhong Chen, Na Xu, Danyang Chong, Shan Guan, Chen Jiang, Zhongzhou Yang and Chaojun Li.

in Cardiovascular Research

June 2018; p ublished online February 2018 .

Journal Article. Subjects: Cardiovascular Medicine. 7182 words.

Abstract

Aims

With the maturation of placenta, ventricular chamber maturation enhances cardiac contractile...

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The gene geranylgeranyl reductase of peach (<i>Prunus persica</i> [L.] Batsch) is regulated during leaf development and responds differentially to distinct stress factors

Donato Giannino, Emiliano Condello, Leonardo Bruno, Giulio Testone, Andrea Tartarini, Radiana Cozza, Anna Maria Innocenti, Maria Beatrice Bitonti and Domenico Mariotti.

in Journal of Experimental Botany

September 2004; p ublished online July 2004 .

Journal Article. Subjects: Plant Sciences and Forestry. 6446 words.

Plant geranylgeranyl hydrogenase (CHL P) reduces free geranylgeranyl diphosphate to phytil diphosphate, which provides the side chain to chlorophylls, tocopherols, and plastoquinones. In...

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Interconversion of the Product Specificity of Type I Eubacterial Farnesyl Diphosphate Synthase and Geranylgeranyl Diphosphate Synthase through One Amino Acid Substitution

Takashi Kawasaki, Yoshimitsu Hamano, Tomohisa Kuzuyama, Nobuya Itoh, Haruo Seto and Tohru Dairi.

in The Journal of Biochemistry

January 2003; p ublished online January 2003 .

Journal Article. Subjects: Biochemistry. 5938 words.

Prenyltransferases catalyze the sequential condensation of isopentenyl diphosphate into prenyl diphosphates with specific chain lengths. Pioneering studies demonstrated that the product...

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Relationship between Intron 4b Splicing of the Rat Geranylgeranyl Diphosphate Synthase Gene and the Active Enzyme Expression Level

Yoshihiro Matsumura, Tsuyoshi Kuzuguchi and Hiroshi Sagami.

in The Journal of Biochemistry

September 2004; p ublished online September 2004 .

Journal Article. Subjects: Biochemistry. 8304 words.

Geranylgeranyl diphosphate synthase (GGPS) is a branch point enzyme in the mevalonate pathway that catalyzes the synthesis of geranylgeranyl diphosphate used for the geranylgeranylation of...

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Effects of Random Mutagenesis in a Putative Substrate-Binding Domain of Geranylgeranyl Diphosphate Synthase upon Intermediate Formation and Substrate Specificity

Shin-ichi Ohnuma, Hisashi Hemmi, Chikara Ohto, Hiroyuki Nakane and Tokuzo Nishino.

in The Journal of Biochemistry

April 1997; p ublished online April 1997 .

Journal Article. Subjects: Biochemistry. 0 words.

Archaeal geranylgeranyl diphosphate (GGPP) synthase catalyzes the consecutive condensation of isopentenyl diphosphate (IPP) with allylic diphosphates to produce GGPP with significant...

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The Carboxyl-terminal Region of the Geranylgeranyl Diphosphate Synthase is Indispensable for the Stabilization of the Region Involved in Substrate Binding and Catalysis

Yoshihiro Matsumura, Tomohiro Kidokoro, Yukino Miyagi, Navya Rani Marilingaiah and Hiroshi Sagami.

in The Journal of Biochemistry

October 2007; p ublished online October 2007 .

Journal Article. Subjects: Biochemistry. 2805 words.

Rat geranylgeranyl diphosphate synthase (GGPS) and its deletion mutants from the carboxyl terminus were analysed using Escherichia coli harbouring pACYC-crtIB, which contains crtI and crtB ...

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Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate

Wen-Chung Tsai, Tung-Yang Yu, Li-Ping Lin, Mei-Ling Cheng, Cheng-Lun Chen and Jong-Hwei S. Pang.

in Toxicological Sciences

February 2016; p ublished online November 2015 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4404 words.

Statins have been reported to induce tendinopathy and even tendon rupture. The present study was designed to investigate the potential molecular mechanism underlying the adverse effect of...

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diterpene

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 39 words.

A large class of natural products (~5000 are known) composed of four isoprene units and derived from geranylgeranyl pyrophosphate. The

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prenylation

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 152 words.

the enzymic addition of prenyl moieties to proteins as a post‐translational modification; geranyl, farnesyl, or geranylgeranyl groups may

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prenylation

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 21 words.

The post-translational modification of protein by the addition of prenyl (farnesyl, geranyl, or geranylgeranyl) groups, which promotes association with membranes.

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