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interactome

Overview page. Subjects: Biological Sciences.

All the interactions that occur between the various molecules produced by an organism, in all its cells and tissues and at all stages of its life. For practical purposes, researchers focus...

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interactome

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 65 words.

The complete set of molecular interactions going on within cells, by analogy with the genome. The interactome, and to a

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interactome

Overview page. Subjects: Biological Sciences.

All the interactions that occur between the various molecules produced by an organism, in all its cells and tissues and at all stages of its life. For practical purposes, researchers focus...

See overview in Oxford Index

interactome

Elizabeth Martin and Robert Hine.

in A Dictionary of Biology

January 2008; p ublished online January 2008 .

Reference Entry. Subjects: Biological Sciences. 255 words.

All the interactions that occur between the various molecules produced by an organism, in all its cells and tissues and

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interactome

Edited by Robert Hine and Elizabeth Martin.

in A Dictionary of Biology

June 2016; p ublished online September 2015 .

Reference Entry. Subjects: Biological Sciences. 328 words.

All the interactions that occur between the various molecules produced by an organism, in all its cells and tissues and

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PAIR: the predicted <i>Arabidopsis</i> interactome resource

Mingzhi Lin, Xueling Shen and Xin Chen.

in Nucleic Acids Research

January 2011; p ublished online October 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 3285 words.

The predicted Arabidopsis interactome resource (PAIR, http://www.cls.zju.edu.cn/pair/), comprised of 5990 experimentally reported molecular interactions in Arabidopsis thaliana together...

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Interactome: gateway into systems biology

Michael E. Cusick, Niels Klitgord, Marc Vidal and David E. Hill.

in Human Molecular Genetics

October 2005; p ublished online October 2005 .

Journal Article. Subjects: Genetics and Genomics. 9121 words.

Protein–protein interactions are fundamental to all biological processes, and a comprehensive determination of all protein–protein interactions that can take place in an organism provides a...

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Local modeling of global interactome networks

Denise Scholtens, Marc Vidal and Robert Gentleman.

in Bioinformatics

January 2005; p ublished online July 2005 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 6416 words.

Motivation: Systems biology requires accurate models of protein complexes, including physical interactions that assemble and regulate these molecular machines. Yeast two-hybrid...

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APID interactomes: providing proteome-based interactomes with controlled quality for multiple species and derived networks

Diego Alonso-López, Miguel A. Gutiérrez, Katia P. Lopes, Carlos Prieto, Rodrigo Santamaría and Javier De Las Rivas.

in Nucleic Acids Research

July 2016; p ublished online April 2016 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4679 words.

APID (Agile Protein Interactomes DataServer) is an interactive web server that provides unified generation and delivery of protein interactomes mapped to their respective proteomes. This...

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PINA v2.0: mining interactome modules

Mark J. Cowley, Mark Pinese, Karin S. Kassahn, Nic Waddell, John V. Pearson, Sean M. Grimmond, Andrew V. Biankin, Sampsa Hautaniemi and Jianmin Wu.

in Nucleic Acids Research

January 2012; p ublished online November 2011 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 1974 words.

The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein–protein interaction data integrated from six manually...

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Toward the dynamic interactome: it's about time

Teresa M. Przytycka, Mona Singh and Donna K. Slonim.

in Briefings in Bioinformatics

January 2010; p ublished online January 2010 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 8506 words.

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along...

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APID2NET: unified interactome graphic analyzer

Juan Hernandez-Toro, Carlos Prieto and Javier De Las Rivas.

in Bioinformatics

September 2007; p ublished online July 2007 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 1347 words.

Motivation: Exploration and analysis of interactome networks at systems level requires unification of the biomolecular elements and annotations that come from many different...

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Characterization of clinical signs in the human interactome

Monica Chagoyen and Florencio Pazos.

in Bioinformatics

June 2016; p ublished online February 2016 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 2936 words.

Motivation: Many diseases are related by shared associated molecules and pathways, exhibiting comorbidities and common phenotypes, an indication of the continuous nature of the...

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UniHI: an entry gate to the human protein interactome

Gautam Chaurasia, Yasir Iqbal, Christian Hänig, Hanspeter Herzel, Erich E. Wanker and Matthias E. Futschik.

in Nucleic Acids Research

P ublished online December 2006 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 2038 words.

Systematic mapping of protein–protein interactions has become a central task of functional genomics. To map the human interactome, several strategies have recently been pursued. The...

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An enhanced Java graph applet interface for visualizing interactomes

Aaron N. Chang, Jason McDermott and Ram Samudrala.

in Bioinformatics

April 2005; p ublished online December 2004 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 964 words.

Summary: We have developed several new navigation features for a Java graph applet previously released for visualizing protein–protein interactions. This graph viewer can be...

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Yeast Protein Interactome topology provides framework for coordinated-functionality

André X. C. N. Valente and Michael E. Cusick.

in Nucleic Acids Research

January 2006; p ublished online January 2006 .

Journal Article. Subjects: Proteins; Molecular Biology and Genetics; Bioinformatics and Computational Biology. 5649 words.

The architecture of the network of protein–protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures,...

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Increasing confidence of protein interactomes using network topological metrics

Jin Chen, Wynne Hsu, Mong Li Lee and See-Kiong Ng.

in Bioinformatics

August 2006; p ublished online June 2006 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 4983 words.

Motivation: Experimental limitations in high-throughput protein–protein interaction detection methods have resulted in low quality interaction datasets that contained sizable...

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The cell-cycle interactome: a source of growth regulators?

Jonas Blomme, Dirk Inzé and Nathalie Gonzalez.

in Journal of Experimental Botany

June 2014; p ublished online December 2013 .

Journal Article. Subjects: Plant Sciences and Forestry. 12897 words.

When plants develop, cell proliferation and cell expansion are tightly controlled in order to generate organs with a determinate final size such as leaves. Several studies have demonstrated...

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Global topological features of cancer proteins in the human interactome

Pall F. Jonsson and Paul A. Bates.

in Bioinformatics

September 2006; p ublished online July 2006 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 4094 words.

Motivation: The study of interactomes, or networks of protein-protein interactions, is increasingly providing valuable information on biological systems. Here we report a study...

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PlanNET: homology-based predicted interactome for multiple planarian transcriptomes

S Castillo-Lara and J F Abril.

Edited by Janet Kelso.

in Bioinformatics

March 2018; p ublished online November 2017 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 6073 words.

Abstract

Motivation

Planarians are emerging as a model organism to study regeneration in animals. However, the...

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Interactome–transcriptome integration for predicting distant metastasis in breast cancer

Maxime Garcia, Raphaelle Millat-Carus, François Bertucci, Pascal Finetti, Daniel Birnbaum and Ghislain Bidaut.

in Bioinformatics

March 2012; p ublished online January 2012 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 5566 words.

Motivation: High-throughput gene expression profiling yields genomic signatures that allow the prediction of clinical conditions including patient outcome. However, these...

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