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munc-13

Overview page. Subjects: Medicine and Health.

One of the CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic vesicles by acting through syntaxin.

See overview in Oxford Index

munc-13

Overview page. Subjects: Medicine and Health.

One of the CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic vesicles by acting through syntaxin.

See overview in Oxford Index

munc-13

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 25 words.

One of the *CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic

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Munc13-2 Differentially Affects Hippocampal Synaptic Transmission and Plasticity

J. Breustedt, A. Gundlfinger, F. Varoqueaux, K. Reim, N. Brose and D. Schmitz.

in Cerebral Cortex

May 2010; p ublished online August 2009 .

Journal Article. Subjects: Neuroscience. 7690 words.

The short-term dynamics of synaptic communication between neurons provides neural networks with specific frequency-filter characteristics for information transfer. The direction of...

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Expression, Purification and Characterization of Critical Domains of Munc13-1

Cong Ma, Hai Hou, Wei Tian and Tao Xu.

Edited by Minghua Xu.

in Acta Biochimica et Biophysica Sinica

August 2007; p ublished online August 2007 .

Journal Article. Subjects: Biochemistry. 0 words.

Munc13-1 is an essential component of synaptic vesicle releasing machinery. Three rat Munc13-1 constructs were rationally designed based on homology and function, overexpressed in Escherich...

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DOC2B and Munc13-1 Differentially Regulate Neuronal Network Activity

Ayal Lavi, Anton Sheinin, Ronit Shapira, Daniel Zelmanoff and Uri Ashery.

in Cerebral Cortex

September 2014; p ublished online March 2013 .

Journal Article. Subjects: Neuroscience. 10516 words.

Alterations in the levels of synaptic proteins affect synaptic transmission and synaptic plasticity. However, the precise effects on neuronal network activity are still enigmatic. Here, we...

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Regulating Secretory Lysosomes

Oliver J. Holt, Federico Gallo and Gillian M. Griffiths.

in The Journal of Biochemistry

July 2006; p ublished online July 2006 .

Journal Article. Subjects: Biochemistry. 5193 words.

Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release...

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Versatile Role of Rab27 in Membrane Trafficking: Focus on the Rab27 Effector Families

Mitsunori Fukuda.

in The Journal of Biochemistry

January 2005; p ublished online January 2005 .

Journal Article. Subjects: Biochemistry. 5687 words.

Rab27A was the only Rab protein whose dysfunction was found to cause human immunodeficiency. Since Griscelli syndrome patients (i.e., Rab27A-deficient) exhibit silvery hair color (i.e.,...

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Molecular Cloning, Expression, and Characterization of a Novel Class of Synaptotagmin (Syt XIV) Conserved from <i>Drosophila</i> to Humans

Mitsunori Fukuda.

in The Journal of Biochemistry

May 2003; p ublished online May 2003 .

Journal Article. Subjects: Biochemistry. 6692 words.

Synaptotagmins (Syts) represent a large family of putative membrane trafficking proteins found in various species from different phyla. In this study, I identified a novel class of Syt...

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Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment

Itziar Gil-Pisa, Eva Munarriz-Cuezva, Alfredo Ramos-Miguel, Leyre Urigüen, J. Javier Meana and Jesús A. García-Sevilla.

in International Journal of Neuropsychopharmacology

June 2012; p ublished online June 2012 .

Journal Article. 7977 words.

Abstract

Munc18-1 and syntaxin-1 are crucial interacting molecules for synaptic membrane fusion and neurotransmitter release. Contrasting abnormalities of...

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CAZ proteins

Overview page. Subjects: Medicine and Health.

A set of multidomain proteins associated with the cytoskeletal matrix at the active zone (CAZ) of synapses in the central nervous system where synaptic vesicles dock, fuse, release their...

See overview in Oxford Index