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munc-13

Overview page. Subjects: Medicine and Health.

One of the CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic vesicles by acting through syntaxin.

See overview in Oxford Index

munc-13

Overview page. Subjects: Medicine and Health.

One of the CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic vesicles by acting through syntaxin.

See overview in Oxford Index

munc-13

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 25 words.

One of the *CAZ proteins (homologue of Caenorhabditis elegans UNC-13 protein, 1591 aa) that promotes the priming of synaptic

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Munc13-2 Differentially Affects Hippocampal Synaptic Transmission and Plasticity

J. Breustedt, A. Gundlfinger, F. Varoqueaux, K. Reim, N. Brose and D. Schmitz.

in Cerebral Cortex

May 2010; p ublished online August 2009 .

Journal Article. Subjects: Neuroscience. 7690 words.

The short-term dynamics of synaptic communication between neurons provides neural networks with specific frequency-filter characteristics for information transfer. The direction of...

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Expression, Purification and Characterization of Critical Domains of Munc13-1

Cong Ma, Hai Hou, Wei Tian and Tao Xu.

Edited by Minghua Xu.

in Acta Biochimica et Biophysica Sinica

August 2007; p ublished online August 2007 .

Journal Article. Subjects: Biochemistry. 0 words.

Munc13-1 is an essential component of synaptic vesicle releasing machinery. Three rat Munc13-1 constructs were rationally designed based on homology and function, overexpressed in Escherich...

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DOC2B and Munc13-1 Differentially Regulate Neuronal Network Activity

Ayal Lavi, Anton Sheinin, Ronit Shapira, Daniel Zelmanoff and Uri Ashery.

in Cerebral Cortex

September 2014; p ublished online March 2013 .

Journal Article. Subjects: Neuroscience. 10516 words.

Alterations in the levels of synaptic proteins affect synaptic transmission and synaptic plasticity. However, the precise effects on neuronal network activity are still enigmatic. Here, we...

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Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment

Itziar Gil-Pisa, Eva Munarriz-Cuezva, Alfredo Ramos-Miguel, Leyre Urigüen, J. Javier Meana and Jesús A. García-Sevilla.

in International Journal of Neuropsychopharmacology

June 2012; p ublished online June 2012 .

Journal Article. 7977 words.

Abstract

Munc18-1 and syntaxin-1 are crucial interacting molecules for synaptic membrane fusion and neurotransmitter release. Contrasting abnormalities of...

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CAZ proteins

Overview page. Subjects: Medicine and Health.

A set of multidomain proteins associated with the cytoskeletal matrix at the active zone (CAZ) of synapses in the central nervous system where synaptic vesicles dock, fuse, release their...

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Enlightening molecular mechanisms through study of protein interactions

Josep Rizo, Michael K. Rosen and Kevin H. Gardner.

in Journal of Molecular Cell Biology

October 2012; p ublished online June 2012 .

Journal Article. Subjects: Molecular and Cell Biology. 9656 words.

The investigation of molecular mechanisms is a fascinating area of current biological research that unites efforts from scientists with very diverse expertise. This review provides a...

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Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

Alfredo Ramos-Miguel, J. Javier Meana and Jesús A. García-Sevilla.

in International Journal of Neuropsychopharmacology

April 2013; p ublished online April 2013 .

Journal Article. 3698 words.

Abstract

Cyclin-dependent kinase-5 (CDK5) and p35/p25 activators, interacting with the exocytotic machinery (e.g. munc18-1 and syntaxin-1A), play critical...

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CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone

Yamato Hida and Toshihisa Ohtsuka.

in The Journal of Biochemistry

August 2010; p ublished online June 2010 .

Journal Article. Subjects: Biochemistry. 4185 words.

Cytomatrix at the active zone-associated structural protein (CAST) was first purified from rat brain. It belongs to a protein family with the protein ELKS being its close relative. In nerve...

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