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peptidyl-tRNA

Overview page. Subjects: Chemistry.

The form in which a growing polypeptide chain is held to a ribosome during polypeptide biosynthesis. The polypeptide is esterified through its C‐terminal carboxyl group to the 3′‐hydroxyl...

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Peptidyl‐tRNA hydrolase from <i>Sulfolobus solfataricus</i>

Michel Fromant, Maria‐Laura Ferri‐Fioni, Pierre Plateau and Sylvain Blanquet.

in Nucleic Acids Research

June 2003; p ublished online June 2003 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7381 words.

An enzyme capable of liberating functional tRNALys from Escherichia coli diacetyl‐lysyl‐tRNALys was purified from the archae Sulfolobus solfataricus. Contrasting with the specificity of...

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Ribosome stalling and peptidyl-tRNA drop-off during translational delay at AGA codons

Luis Rogelio Cruz-Vera, Marco Antonio Magos-Castro, Efraín Zamora-Romo and Gabriel Guarneros.

in Nucleic Acids Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5968 words.

Minigenes encoding the peptide Met–Arg–Arg have been used to study the mechanism of toxicity of AGA codons proximal to the start codon or prior to the termination codon in bacteria. The...

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Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase

Kosuke Ito, Ryo Murakami, Masahiro Mochizuki, Hao Qi, Yoshihiro Shimizu, Kin-ichiro Miura, Takuya Ueda and Toshio Uchiumi.

in Nucleic Acids Research

November 2012; p ublished online August 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7172 words.

Peptidyl-tRNA hydrolase (Pth) cleaves the ester bond between the peptide and the tRNA of peptidyl-tRNA molecules, which are produced by aborted translation, to recycle tRNA for further...

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peptidyl-tRNA

Overview page. Subjects: Chemistry.

The form in which a growing polypeptide chain is held to a ribosome during polypeptide biosynthesis. The polypeptide is esterified through its C‐terminal carboxyl group to the 3′‐hydroxyl...

See overview in Oxford Index

Reliable semi-synthesis of hydrolysis-resistant 3′-peptidyl-tRNA conjugates containing genuine tRNA modifications

Dagmar Graber, Holger Moroder, Jessica Steger, Krista Trappl, Norbert Polacek and Ronald Micura.

in Nucleic Acids Research

October 2010; p ublished online June 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4438 words.

The 3′-peptidyl-tRNA conjugates that possess a hydrolysis-resistant ribose-3′-amide linkage instead of the natural ester linkage would represent valuable substrates for ribosomal studies....

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peptidyl‐tRNA

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 43 words.

the form in which a growing polypeptide chain is held to a ribosome during polypeptide biosynthesis. The polypeptide is esterified

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A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in <i>Escherichia coli</i>

Nongmaithem Sadananda Singh and Umesh Varshney.

in Nucleic Acids Research

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6662 words.

The bacterial ssrA gene codes for a dual function RNA, tmRNA, which possesses tRNA-like and mRNA-like regions. The tmRNA appends an oligopeptide tag to the polypeptide on the P-site tRNA by...

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An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination

Melanie Amort, Brigitte Wotzel, Kamilla Bakowska-Zywicka, Matthias D. Erlacher, Ronald Micura and Norbert Polacek.

in Nucleic Acids Research

August 2007; p ublished online July 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7222 words.

Peptide bond formation and peptidyl-tRNA hydrolysis are the two elementary chemical reactions of protein synthesis catalyzed by the ribosomal peptidyl transferase ribozyme. Due to the...

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Excess of charged tRNA<sup>Lys</sup> maintains low levels of peptidyl-tRNA hydrolase in <i>pth</i>(Ts) mutants at a non-permissive temperature

Serafin Vivanco-Domínguez, Luis Rogelio Cruz-Vera and Gabriel Guarneros.

in Nucleic Acids Research

March 2006; p ublished online March 2006 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4971 words.

Cellular changes have been monitored during the suppression, mediated by the overproduction of tRNALys, of thermosensitivity in Escherichia coli strain AA7852 carrying a mutation in...

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Crystal structure of <i>Staphylococcus aureus</i> peptidyl-tRNA hydrolase at a 2.25 Å resolution

Fan Zhang, Yang Song, Liwen Niu, Maikun Teng and Xu Li.

in Acta Biochimica et Biophysica Sinica

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Biochemistry. 4165 words.

Peptidyl-tRNA hydrolase (Pth) catalyzes the release of tRNA to relieve peptidyl-tRNA accumulation. Because Pth activity is essential for the viability of bacteria, Pth is regarded as a...

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