Journal Article

The <i>Brugia malayi</i> genome project: expressed sequence tags and gene discovery

Mark Blaxter, Jennifer Daub, David Guiliano, John Parkinson and Claire Whitton

in Transactions of The Royal Society of Tropical Medicine and Hygiene

Published on behalf of Royal Society of Tropical Medicine and Hygiene

Volume 96, issue 1, pages 7-17
Published in print February 2002 | ISSN: 0035-9203
Published online February 2002 | e-ISSN: 1878-3503 | DOI: http://dx.doi.org/10.1016/S0035-9203(02)90224-5
The Brugia malayi genome project: expressed sequence tags and gene discovery

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Abstract

To advance and facilitate molecular studies of Brugia malayi, one of the causative agents of human lymphatic filariasis, an expressed sequence tag (EST)-based gene discovery programme has been carried out. Over 22 000 ESTs have been produced and deposited in the public databases by a consortium of laboratories from endemic and non-endemic countries. The ESTs have been analysed using custom informatic tools to reveal patterns of individual gene expression that may point to potential targets for future research on anti-filarial drugs and vaccines. Many genes first discovered as ESTs are now being analysed by researchers for immunodiagnostic, vaccine and drug target potential. Building on the success of the B. malayi EST programme, significant EST datasets are being generated for a number of other major parasites of humans and domesticated animals, and model parasitic species.

Keywords: Brugia malayi; nematodes; filariae; genetic analysis; genome; expressed sequence tags; Wolbachia

Journal Article.  0 words. 

Subjects: Clinical Medicine ; Infectious Diseases ; Immunology ; Medical Microbiology and Virology ; Public Health and Epidemiology

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