Journal Article

Molecular and biochemical analysis of the system regulating the lytic/lysogenic cycle in the pneumococcal temperate phage MM1

Virginia Obregón, Pedro García, Rubens López and José L. García

in FEMS Microbiology Letters

Volume 222, issue 2, pages 193-197
Published in print May 2003 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI: https://dx.doi.org/10.1016/S0378-1097(03)00281-7

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Abstract

The temperate phage MM1 forms stable lysogens in Streptococcus pneumoniae. We report here the first characterization of the lysogenic control region in Pneumococcus which contains two functional divergent promoters (PR and Pl). MM1 encodes a 14-kDa cI protein (CI) that appears to be responsible for maintaining the lysogenic state in Pneumococcus since it prevents elongation of the transcripts controlled by PR and Pl.

Keywords: Phage repressor; Lytic/lysogenic cycle; Temperate phage; Pneumococcus

Journal Article.  2236 words.  Illustrated.

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