Journal Article

Isolated tissue models and proarrhythmia

M.R. Rosen

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 3, issue suppl_K, pages K64-K69
Published in print September 2001 | ISSN: 1520-765X
Published online September 2001 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/S1520-765X(01)90008-2
Isolated tissue models and proarrhythmia

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Awareness of QT prolongation and torsades de pointes resulting from non-cardiac drug administration has stressed the need for screening procedures to limit development of drugs whose repolarization profile denotes excess risk. This paper focuses on isolated tissue screens, although the linkages of these with molecular/biophysical and intact animal screens is discussed as well. It is suggested that the use of single models, while promoting definitive conclusions, may increase the incidence of incorrect decisions (due to narrowness of focus). Rather, the use of several models/screens is suggested to be most likely to facilitate accurate decision-making.

Keywords: Acquired long QT syndrome; torsades de pointes; early afterdepolarizations; delayed rectifier current

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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