Journal Article

Tibolone: a tissue-specific approach to the menopause

S. Palacios

in European Heart Journal Supplements

Volume 3, issue suppl_M, pages M12-M16
Published in print October 2001 | ISSN: 1520-765X
Published online October 2001 | e-ISSN: 1554-2815 | DOI:
Tibolone: a tissue-specific approach to the menopause

Show Summary Details


Tibolone, a synthetic steroid that is used for hormone replacement in menopausal women, is metabolized to three primary active agents: 3-alpha-hydroxy-tibolone; 3-betahydroxy-tibolone; and [math]-tibolone. It can exhibit oestrogenic, progestogenic or androgenic activity, depending primarily on the target tissue involved; for this reason, tibolone is said to have tissue-specific activity. Oestrogenic effects on vasomotor symptoms, the vagina and bone mean that tibolone is effective in the management of climacteric symptoms and bone loss. However, it does not cause oestrogenic stimulation of the endometrium or breast tissue, thus reducing the risk for side effects such as bleeding and breast tenderness.

Keywords: Hormone replacement therapy; menopause; tibolone; tissue-specific activity

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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