Journal Article

Genetic factors in atherosclerosis: status and perspectives

C. Indolfi

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 4, issue suppl_B, pages B14-B16
Published in print March 2002 | ISSN: 1520-765X
Published online March 2002 | e-ISSN: 1554-2815 | DOI: https://dx.doi.org/10.1016/S1520-765X(02)90010-6
Genetic factors in atherosclerosis: status and perspectives

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Genes contribute to both the cause and the pathogenesis of virtually all abnormalities of human physiology and behaviour, including, of course, atherosclerosis. A variety of genetic factors, in addition to well studied errors of lipid metabolism, clearly predispose to atherosclerosis. Few genes apart other than those involved in lipid metabolism have such an over-whelming impact that they may be identified on the basis of family history. However, genes that predispose to hypertension and diabetes mellitus; control arterial diameter, reactivity and branching angles; affect platelet adhesiveness, thrombosis and fibrinolysis; and regulate endothelial and smooth muscle function can all be considered candidate genes for study in families predisposed to atherosclerosis.

Keywords: Atherosclerosis; genes; polymorphisms

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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