Journal Article

Antioxidants and atherosclerosis

F. Violi, F. Micheletta and L. Iuliano

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 4, issue suppl_B, pages B17-B21
Published in print March 2002 | ISSN: 1520-765X
Published online March 2002 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/S1520-765X(02)90011-8
Antioxidants and atherosclerosis

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A large body of evidence supports the hypothesis that oxidation of low-density lipoprotein plays a key role in atherogenesis. Experimental atherosclerosis in animals can be prevented by natural and synthetic antioxidants. Clinical trials with anti-oxidants, which mainly used vitamin E, showed contrasting findings. Thus, among five secondary prevention trials with vitamin E, three were negative and two were positive. Several factors have been suggested to explain these conflicting results, including compliance, trial design, the dosage used and the source of vitamin E. Thus, the results of clinical trials leave open the issue of antioxidant treatment in human atherosclerosis.

Keywords: Antioxidants; atherosclerosis; oxidative stress

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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