Journal Article

The unstable plaque

G.F. Gensini and B. Dilaghi

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 4, issue suppl_B, pages B22-B27
Published in print March 2002 | ISSN: 1520-765X
Published online March 2002 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/S1520-765X(02)90012-X
The unstable plaque

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Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.

Keywords: Atherosclerosis; passivation; plaque

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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