Journal Article

Intermittent claudication and endothelial dysfunction

A. Silvestro, G. Oliva and G. Brevetti

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 4, issue suppl_B, pages B35-B40
Published in print March 2002 | ISSN: 1520-765X
Published online March 2002 | e-ISSN: 1554-2815 | DOI:
Intermittent claudication and endothelial dysfunction

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The endothelium regulates homeostasis in healthy blood vessels. When affected by injurious stimuli it becomes dysfunctional, thus eliciting changes that predispose to atherosclerosis. Patients with intermittent claudication show a systemic endothelial dysfunction that may result from a variety of factors. In particular, inflammation could play a key role because, in claudicants, endothelial dysfunction negatively correlates with plasma levels of high-sensitivity C-reactive protein, an acute-phase reactant. Future studies will clarify whether interventions that improve endothelial function will improve the clinical outcome of patients with peripheral arterial disease by reducing their cardiovascular risk.

Keywords: C-reactive protein; endothelial dysfunction; inflammation; intermittent claudication; peripheral arterial disease

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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