Journal Article

The fate of the claudicant limb

G.M. Andreozzi and R. Martini

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 4, issue suppl_B, pages B41-B45
Published in print March 2002 | ISSN: 1520-765X
Published online March 2002 | e-ISSN: 1554-2815 | DOI:
The fate of the claudicant limb

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Intermittent claudication deteriorates in no more than 25% of patients. Distance walked on a treadmill is not a precise indicator of outcome, because the same impairment may result in severe limitation for one patient, but may not affect quality of life as judged by another. Only 18% of claudicant patients require surgical revascularization over 10 years, and smoking and ankle-brachial index are the most important markers of this type of surgery. Progression of claudication in critical leg ischaemia varies from 3.8% to 25% (5-year follow-up) and to 41% (8-year follow-up), and the amputation rate is approximately 10% (10-year follow-up). Inflammation and endothelial dysfunction appear to be the major risk factors for progression, but their occurrence is unpredictable and differs from patient to patient; consequently, further studies are required to clarify these aspects.

Keywords: Amputation; critical leg ischaemia; inflammation; intermittent claudication; peripheral arterial disease; treadmill

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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