Journal Article

Interferon-γ and atherosclerosis: Pro- or anti-atherogenic?

Elizabeth J. Harvey and Dipak P. Ramji

in Cardiovascular Research

Published on behalf of European Society of Cardiology

Volume 67, issue 1, pages 11-20
Published in print July 2005 | ISSN: 0008-6363
Published online July 2005 | e-ISSN: 1755-3245 | DOI:
Interferon-γ and atherosclerosis: Pro- or anti-atherogenic?

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Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-γ (IFN-γ) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-γ regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-γ in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-γ signaling.

Keywords: Atherosclerosis; Cytokines; Foam cell; Inflammation; Interferon-γ

Journal Article.  7692 words.  Illustrated.

Subjects: Cardiovascular Medicine

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