Journal Article

A case of EBV driven haemophagocytic lymphohistiocytosis complicating a teenage Crohn's disease patient on azathioprine, successfully treated with rituximab

Michael P. Fitzgerald, Lawrence Armstrong, Rosie Hague and Richard K. Russell

in Journal of Crohn's and Colitis

Volume 7, issue 4, pages 314-314
Published in print May 2013 | ISSN: 1873-9946
Published online May 2013 | e-ISSN: 1876-4479 | DOI: https://dx.doi.org/10.1016/j.crohns.2012.05.002
A case of EBV driven haemophagocytic lymphohistiocytosis complicating a teenage Crohn's disease patient on azathioprine, successfully treated with rituximab

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Abstract

We report a case of Epstein–Barr virus infection with the subsequent development of haemophagocytic lymphohistiocytosis in a teenage Crohn's disease patient treated with azathioprine. We found that the early introduction of the anti-B cell monoclonal antibody rituximab precipitated a rapid fall in circulating B-cells and EBV viral load, resulting in a prompt and sustained recovery from what is a potentially fatal complication of azathioprine therapy in Crohn's disease patients.

Keywords: Crohn's disease; Azathioprine; Haemophagocytic lymphohistiocytosis; Epstein Barr virus; Rituximab

Journal Article.  2457 words. 

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