Journal Article

Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting

Olga Gorchakova, Nicolas von Beckerath, Meinrad Gawaz, Adrienne Mocz, Alexander Joost, Albert Schömig and Adnan Kastrati

in European Heart Journal

Published on behalf of European Society of Cardiology

Volume 25, issue 21, pages 1898-1902
Published in print November 2004 | ISSN: 0195-668x
Published online November 2004 | e-ISSN: 1522-9645 | DOI: http://dx.doi.org/10.1016/j.ehj.2003.10.039
Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting

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Aims

To test prospectively whether the antiplatelet effect of a 600 mg loading dose of clopidogrel is attenuated in patients receiving atorvastatin and simvastatin for at least 4 weeks prior to coronary artery stenting.

Methods and results

Blood samples were obtained at least 2 h after receiving 100 mg aspirin and 600 mg clopidogrel and prior to coronary stenting from 90 patients without statin therapy and 90 patients with statin (atorvastatin and simvastatin) therapy for at least 4 weeks. Maximal and residual platelet aggregation was evaluated with optical aggregometry in response to ADP (5 and 20 μmol/l). Surface expression of IIb/IIIa (CD61) and P-selectin (CD62) was assessed with whole blood flow-cytometry at baseline and following stimulation (5 and 20 μmol/l ADP). Inhibition of ADP-induced platelet aggregation was not impaired in the presence of concomitant statin therapy. Moreover, patients with and without statin therapy did not differ in respect to all flow-cytometric parameters obtained.

Conclusion

The antiplatelet effect of a high, 600 mg loading dose of clopidogrel is not diminished in patients receiving atorvastatin and simvastatin for at least 4 weeks prior to coronary stenting.

Journal Article.  2476 words.  Illustrated.

Subjects: Cardiovascular Medicine

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