Journal Article

Evolution of statin therapy: an ongoing story

O Faergeman

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 6, issue suppl_A, pages A3-A7
Published in print March 2004 | ISSN: 1520-765X
Published online March 2004 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/j.ehjsup.2004.01.002
Evolution of statin therapy: an ongoing story

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Major clinical end-point trials of cholesterol lowering with statins have shown consistent benefits in prevention of cardiovascular disease. Lessons from these trials include the findings that cardiovascular risk reduction is: (1) dependent on baseline cardiovascular risk; (2) dependent on magnitude of low-density lipoprotein cholesterol (LDL-C) reduction achieved with treatment; and (3) independent of initial LDL-C level. Ongoing studies will help to identify new markers of higher risk/higher treatment benefit and to define the merits of more aggressive LDL-C lowering.

Keywords: Statins; Cholesterol lowering; Cardiovascular disease risk; Low-density lipoprotein; Coronary heart disease

Journal Article.  2005 words.  Illustrated.

Subjects: Cardiovascular Medicine

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