Journal Article

Improving outcomes through statin therapy – a review of ongoing trials

C Packard

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 6, issue suppl_A, pages A28-A31
Published in print March 2004 | ISSN: 1520-765X
Published online March 2004 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/j.ehjsup.2004.01.007
Improving outcomes through statin therapy – a review of ongoing trials

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Statin treatment reduces cardiovascular risk in a wide variety of patients. Ongoing studies seek to define better the full range of benefits of such treatment. The issue of how far low-density lipoprotein cholesterol should be lowered for optimal reduction of coronary heart disease risk is being assessed in the TNT, IDEAL and SEARCH trials. The relationships among statin treatment, cardiovascular outcomes and levels of the inflammatory marker C-reactive protein are being assessed in the PROVE-IT and JUPITER trials. Mechanisms for the effects of statin treatment in preventing recurrent events when given early after occurrence of acute coronary syndromes are being examined in the LUNAR trial. The potential benefits of statin therapy in the setting of chronic heart failure are being evaluated in the CORONA, GISSI-HF and UNIVERSE trials. The results of these trials will provide important information on how to maximise the therapeutic benefits of statins in a broader range of patients at risk for cardiovascular morbidity and mortality.

Keywords: Statins; Cardiovascular disease; C-reactive protein; Acute coronary syndromes; LDL cholesterol; Coronary heart disease

Journal Article.  2554 words.  Illustrated.

Subjects: Cardiovascular Medicine

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