Journal Article

Structural, electrical and mechanical remodeling of the canine heart in AV-block and LBBB

Maaike Peschar, Kevin Vernooy, Richard N Cornelussen, Xander A.A.M Verbeek, Robert S Reneman, Marc A Vos and Frits W Prinzen

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 6, issue suppl_D, pages D61-D65
Published in print August 2004 | ISSN: 1520-765X
Published online August 2004 | e-ISSN: 1554-2815 | DOI: http://dx.doi.org/10.1016/j.ehjsup.2004.05.017
Structural, electrical and mechanical remodeling of the canine heart in AV-block and LBBB

Show Summary Details

Preview

Long lasting alterations in loading conditions lead to adaptations in structural remodeling (hypertrophy, changes in the size of the cardiac muscle and the cavity and its connective tissue content), mechanical remodeling (abnormal contraction and relaxation of the heart) and electrical remodeling (increased sensitivity to arrhythmias). In canine hearts with atrioventricular (AV)-block (bradycardia-induced volume overload) the three kinds of remodeling follow different time courses, emphasizing the complexity of myocardial adaptation processes. This is further emphasized by the lack of reversibility of electrical remodeling when normalizing volume load by pacing at physiological heart rate. Evidence is increasing that long lasting asynchronous activation (ventricular pacing, left bundle branch block) leads to eccentric hypertrophy with regional differences in structural, electrical and mechanical remodeling.

Keywords: Hypertrophy; Action potential duration; Force frequency relation; Reverse remodeling; Left bundle branch block

Journal Article.  2835 words.  Illustrated.

Subjects: Cardiovascular Medicine

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.