Journal Article

Influence of QRS prolongation on the natural history of CHF

Luigi Padeletti, Marzia Giaccardi, Federico Turreni, Nicola Musilli, Andrea Colella, Paolo Pieragnoli, Antonio Michelucci, Giuseppe Ricciardi and Maria Cristina Porciani

in European Heart Journal Supplements

Published on behalf of European Society of Cardiology

Volume 6, issue suppl_D, pages D79-D82
Published in print August 2004 | ISSN: 1520-765X
Published online August 2004 | e-ISSN: 1554-2815 | DOI:
Influence of QRS prolongation on the natural history of CHF

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Aims To evaluate the influence of QRS prolongation on the natural history of chronic heart failure (CHF).

Methods The results of several studies carried out from 1951 to 2003 were analysed.

Results (a) Isolated left bundle branch block (LBBB) is associated with an increased risk of developing cardiovascular disease and increased cardiac mortality; (b) investigations on the effect of right bundle branch block (RBBB) on mortality have yelded conflicting results; (c) the effects of the association of LBBB with left axis deviation (LAD) on further LV function deterioration remain controversial; (d) LBBB in CHF is associated with a significantly higher all-cause and sudden cardiac death mortality.

Conclusions LBBB is unequivocably associated with greater disease severity and mortality in patients with CHF.

Keywords: Heart failure; QRS duration; Bundle branch block; Mortality

Journal Article.  2667 words. 

Subjects: Cardiovascular Medicine

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