Journal Article

Echocardiographic indices of left ventricular diastolic dysfunction in 647 individuals with preserved left ventricular systolic function

Frants Pedersen, Ilan Raymond, Lene H. Madsen, Jesper Mehlsen, Dan Atar and Per Hildebrandt

in European Journal of Heart Failure

Published on behalf of European Society of Cardiology

Volume 6, issue 4, pages 439-447
Published in print June 2004 | ISSN: 1388-9842
Published online June 2004 | e-ISSN: 1879-0844 | DOI: http://dx.doi.org/10.1016/j.ejheart.2003.12.003
Echocardiographic indices of left ventricular diastolic dysfunction in 647 individuals with preserved left ventricular systolic function

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Background:

Knowledge about the occurrence of isolated diastolic dysfunction (DD) in the general population is limited.

Aims:

This population study was performed to assess the frequency and distribution pattern of echocardiographic indices of left ventricular (LV) DD in an elderly population aged 50–89 years in which LV systolic function is preserved.

Methods and results:

The study population (n=764) recruited from the background population answered a heart failure questionnaire and underwent echocardiography. Excluding subjects with a LV ejection fraction <50% or atrial fibrillation, diastolic function was evaluated in 647 subjects. The frequency of impaired relaxation according to earlier guidelines was 0.5%, vs. 2.5% using age- and gender-specific normal values of ‘E/A-ratio’ and ‘deceleration time’. In a subpopulation of 167 participants, 6.6% had ‘pseudonormalisation’. No difference was found in the frequency of dyspnea in subjects with impaired relaxation or ‘pseudonormalisation’ compared to subjects with normal filling pattern.

Conclusion:

The prevalence of LV impaired relaxation was highly dependent on the choice of normal (cut-off) values for Doppler indices. Furthermore, our findings suggest that either isolated DD is often asymptomatic, or that Doppler flow derived parameters as a diagnostic method for assessing DD have a low specificity when used as a screening tool in the general population.

Keywords: Diastolic dysfunction; Heart failure; Echocardiography; Epidemiology

Journal Article.  4509 words.  Illustrated.

Subjects: Cardiovascular Medicine

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