Journal Article

B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts

Jens Peter Goetze, Jens F. Rehfeld, Regitze Videbaek, Lennart Friis-Hansen and Jens Kastrup

in European Journal of Heart Failure

Published on behalf of European Society of Cardiology

Volume 7, issue 1, pages 69-74
Published in print January 2005 | ISSN: 1388-9842
Published online January 2005 | e-ISSN: 1879-0844 | DOI: https://dx.doi.org/10.1016/j.ejheart.2004.04.012
B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts

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Background:

Plasma concentrations of B-type natriuretic peptide (BNP-32) and its precursor (proBNP) are increased in chronic heart failure. Accordingly, BNP-32 and proBNP are both being implemented as clinical markers.

Aim:

To determine the molar relation of BNP-32 and proBNP in different cardiovascular regions.

Methods and results:

Blood samples were obtained from different cardiovascular regions during right heart catheterization in heart failure patients, and from normal subjects. Plasma BNP-32 and proBNP concentrations were measured using sequence-specific radioimmunoassays. Patients with severe left ventricular dysfunction (n=21) displayed increased peripheral plasma concentrations of both BNP-32 (four-fold, P=0.0008) and proBNP (seven-fold, P=0.0002) compared with normal subjects. Moreover, the peripheral concentrations were highly correlated with the corresponding concentrations in the coronary sinus (BNP-32: r=0.97, P<0.0001; proBNP: r=0.94, P<0.0001). Despite comparable peripheral concentrations of BNP-32 and proBNP, the BNP-32 concentration was higher than the proBNP concentration in the coronary sinus (median 126 pmol/l (21–993) vs. 103 pmol/l (16–691), P=0.035).

Conclusions:

The BNP-32 and proBNP concentrations are closely related in venous cardiac blood. The findings suggest an overall constitutive secretion of processed proBNP, i.e. an N-terminal precursor fragment and BNP-32, in chronic heart failure.

Keywords: B-type natriuretic peptide; Cardiac secretion; Heart failure; Natriuretic peptide; proBNP

Journal Article.  2899 words.  Illustrated.

Subjects: Cardiovascular Medicine

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