Journal Article

P.2. Syncope, Pacemaker, CRT & ICD

X. Good, M. Chin, K. Kemnitzer, H. Krätschmer and K. Foley

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 7, issue s3, pages S44-S45
Published in print October 2005 | ISSN: 1099-5129
Published online October 2005 | e-ISSN: 1532-2092 | DOI:
P.2. Syncope, Pacemaker, CRT & ICD

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The physiologic Closed Loop Stimulation (CLS) sensor translates localized myocardial impedance via an RV endocardial lead into pacing rates. CLS rate adaptation using non-traditional Bi-V lead configurations is unknown and was investigated.


We examined acute (hall walk) and long-term rate adaptations over 7-14 months post implant in 5 CLS pacemaker patients with various non-traditional Bi-V configurations, positioning leads at RV apex and/or outflow tract, LV epicardium, or coronary sinus, with/without Y adaptors.


Hall walks after CLS activation showed acute rate support in 4 of 4 patients tested. Patients were then CLS Bi-V paced for 6 to 8 months. Total atrial pacing varied 57-99% among 5 patients. CLS sensor-driven pacing occurred 22-95% of the time and spanned the full range between lower and maximum sensor rates for all patients.


CLS provides rate-adaptive pacing in response to patients' metabolic needs during chronic and acute situations using non-traditional lead configurations. CLS rate adaptation may contribute physiologic benefits to CHF pts undergoing CRT and warrants further investigation.

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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