Journal Article

P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

E. Mcneill, R. Gagnon, J. Potts, C. Kerr, J. Yeung Wai-Lah and S. Sanatani

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 7, issue s3, pages S47-S47
Published in print October 2005 | ISSN: 1099-5129
Published online October 2005 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1016/j.eupc.2005.08.193
P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

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Objective

To assess cerebral cortical oxygenation and cellular homeostasis during EPS and RF ablation, using near infrared spectroscopy.

Methods

Standard EPS was performed in 11 sedated patients (female = 6, mean age = 45 ± 11 years) with symptomatic SVT documented on ECG and no pre-existing cardiovascular or cerebrovascular disease. A NIRO-300 spectrophotometer was used to continuously measure absolute changes in the concentrations of chromophores which reflect intravascular and mitochondrial levels of oxygenation, namely oxygenated haemoglobin (hbo2), deoxygenated haemoglobin (Hb) and the net redox status of cytochrome c oxidase (cyt-a,a3). MABP was monitored simultaneously.

Results

RF ablations were performed on 10 patients [AV nodal reentrant tachycardia=6; AV reentrant tachycardia= 4; cycle length = 348 ± 69 msec (range: 225-425 msec)]. No significant changes occurred in hbo2, Hb and cyt-a,a3 during atrial and ventricular EPS pacing protocols, induced SVT, or RF ablation. MABP decreased during pacing at cycle lengths < 400 msec (p<0.005).

Conclusion

Cellular energy dynamics were stable during atrial and ventricular pacing, SVT, and RF ablation. This data suggests that overall cerebral tissue oxygenation is preserved during EPS.

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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