Journal Article

P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

I. Tangodan, H. Aslan, Y. Aksoy, E. Topal, O. Turgut, A. Yilmaz, N. Acikgoz, F. Kosar and R. Ozdemir

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 7, issue s3, pages S49-S49
Published in print October 2005 | ISSN: 1099-5129
Published online October 2005 | e-ISSN: 1532-2092 | DOI: https://dx.doi.org/10.1016/j.eupc.2005.08.204
P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

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Objective

The aim of this study is to asses the effect of the presence of coronary collateral circulation (CCC) on QT dispersion (QTD) in coronary artery disease (CAD).

Background

Deaths in chronic CAD patients are often a consequence of arrhythmia. A prolonged QTD is considered an indicator of increased risk of malignant ventricular arrhythmias. The functional significance of CCC presence in CAD has not been fully understood.

Method

Consistent with Rentrop Scoring, CCC presence and corrected QTD (qtcd) were established in the patients diagnosed with at least 85% stenosis in left anterior descending coronary artery or in proximal part or in the body of the right coronary artery. Furthermore, left ventricular function score was determined for all the patients and its impact on the outcome was assessed.

Results

While CCC was absent (CCC grade 0) in 32 patients, 68 patients were found to have CCC (CCC grade ≥ 1). Mean qtcd was greater in patients who were CCC grade ≥ 1, compared with that of patients who were grade 0 (64.3 ± 3.5, 46.8 ± 2.7 respectively, p=0.002). Mean qtcd for grade 3 CCC patients was significantly higher than that of the grade 0 patients (p=0.003). CCC grade ≥ 1 patients had higher mean left ventricular function scores than grade 0 patients (p = 0.048). The increase in left ventricular function score and qtcd were observed to be correlated (p = 0.046, r = 0.200).

Conclusion

CCC presence in patients with chronic CAD does not seem to have a positive effect on qtcd; on the contrary, qtcd values are higher when well-developed CCC is observed. Further research on larger patient populations based on long-term follow up is required to investigate this issue.

Journal Article.  0 words. 

Subjects: Cardiovascular Medicine

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