Journal Article

P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

A. Oto, B. Yavuz, U. Duman, A. Yazıcıoglu, G. Abali, L. Sahiner, K. Aytemir, M. Demircin, L. Tokgozoglu and Nasih Nazli

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 7, issue s3, pages S50-S50
Published in print October 2005 | ISSN: 1099-5129
Published online October 2005 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1016/j.eupc.2005.08.206
P.3. Basic Science, Sudden Death Risk Stratification and Ventricular Arrhythmias

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Objectives

Although the influence of CABG on the autonomic nervous system has been well documented in studies using pre- and postoperative HRV analysis, the impact of CABG on QT dynamicity has not been studied. QT dynamicity that can be measured by the slope of the linear regression of QT/RR, reflects abnormal rate adaptation of ventricular repolarization. This study evaluated the effects of CABG on QT interval dynamicity in subjects with coronary artery disease.

Methods

The study group consisted of 47 consecutive patients with coronary artery disease who underwent elective CABG. All subjects had a complete history, laboratory examination and transthorasic echocardiography. Twenty-four-hour Holter monitoring was performed 2 to 5 days before cardiac surgery and was repeated 10 days after CABG. Recordings, which were obtained using 3-channel analog recorders and analyzed using the ELATEC hoter system, were used to calculate mean heart rate and QT dynamicity parameters.

Results

Mean value of left ventricular ejection fraction was 53.3±7.1. Qtend/RR and qtapex/RR slope were significantly increased in the early postoperative period after CABG (qtapex/RR: 0,15±0,12, 0,27±0, p=0.001; qtend/RR: 0.17±0.21, 0.35±0.23, p<0.001) (Table 1).

Conclusions

CABG was associated with a significant worsening of QT dynamicity parameters in the early postoperative period. Perioperative damage of autonomic nervous fibers, may play a role in QT dynamicity worsening.

Journal Article.  0 words.  Illustrated.

Subjects: Cardiovascular Medicine

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