Journal Article

Anti-complement effects of lactoferrin-derived peptides

Ørjan Samuelsen, Hanne H. Haukland, Hilde Ulvatne and Lars H. Vorland

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 41, issue 2, pages 141-148
Published in print June 2004 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1016/j.femsim.2004.02.006
Anti-complement effects of lactoferrin-derived peptides

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Abstract

Lactoferrin is an important biological molecule with many functions such as modulation of the inflammatory response, iron metabolism and antimicrobial defense. One effect of lactoferrin is the inhibition of the classical complement pathway. This study reports that antimicrobial peptides derived from the N-terminal region from both human and bovine lactoferrin, lactoferricin H and lactoferricin B, respectively, inhibit the classical complement pathway. No inhibitory effect of these peptides was observed on the alternative complement pathway in an AP50 assay. However, lactoferricin B reduced the inhibitory properties of serum against Escherichia coli in a concentration dependent manner. These results suggest that the N-terminal region of lactoferrin is the important part in the inhibition of complement activation and that these peptides possess other important properties than their antimicrobial effect.

Keywords: Antimicrobial peptides; Lactoferrin; Lactoferricin; Complement inhibition

Journal Article.  3782 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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