Journal Article

Vitamin B<sub>3</sub> confers resistance to sulfa drugs in <i>Saccharomyces cerevisiae</i>

Olga Kornfeld and Brian P. Nichols

in FEMS Microbiology Letters

Volume 251, issue 1, pages 137-141
Published in print October 2005 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI: https://dx.doi.org/10.1016/j.femsle.2005.07.037

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Abstract

Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance.

Keywords: Nicotinate; Sulfonamide resistance; Sulfamethoxazole; Sulfathiazole; Folate

Journal Article.  2321 words.  Illustrated.

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