Journal Article

Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD

Laurence L. Greenhill, James M. Perel, George Rudolph, Bruce Feldman, Susan Curran, Joaquim Puig-Antich and Richard Gardner

in International Journal of Neuropsychopharmacology

Published on behalf of International College of Neuropsychopharmacology

Volume 4, issue 2, pages 207-215
Published in print June 2001 | ISSN: 1461-1457
Published online June 2001 | e-ISSN: 1469-5111 | DOI: https://dx.doi.org/10.1017/S1461145701002413
Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD

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Abstract

Following a 0.9 mg/kg methylphenidate loading dose, serial plasma level determinations, self-scored mood ratings, and measures of motor persistence were gathered on eight previously unmedicated boys with attention deficit disorder with hyperactivity (ADHD) during a 9-h period. The measures were repeated using the same loading dose after 6 months of maintenance treatment with methylphenidate (1.3 mg/kg.d). Kinetic-dynamic modelling suggests inverse correlative relationships between motor performance errors and plasma levels. Pharmacokinetic parameters did not change between acute and maintenance drug treatment phases, and there was no evidence of long-term tolerance.

Keywords: Methylphenidate; kinetic-dynamic; motor persistence; plasma level; ADHD

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