Journal Article

Acute Lung Injury in Leptospirosis: Clinical and Laboratory Features, Outcome, and Factors Associated with Mortality

Paulo C. F. Marotto, Cristiane M. R. Nascimento, Jose Eluf-Neto, Marcia S. Marotto, Lucia Andrade, Jaques Sztajnbok and Antonio C. Seguro

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 6, pages 1561-1563
Published in print December 1999 | ISSN: 1058-4838
Published online December 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313501
Acute Lung Injury in Leptospirosis: Clinical and Laboratory Features, Outcome, and Factors Associated with Mortality

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Forty-two consecutive patients with leptospirosis and acute lung injury who were mechanically ventilated were analyzed in a prospective cohort study. Nineteen patients (45%) survived, and 23 (55%) died. Multivariate analysis revealed that 3 variables were independently associated with mortality: hemodynamic disturbance (odds ratio [OR], 6.0; 95% confidence interval [CI], 0.9–38.8; P=.047), serum creatinine level >265.2 µmol/L (OR, 10.6; 95% CI, 0.9–123.7; P =.026), and serum potassium level >4.0 mmol/L (OR, 19.9; 95% CI, 1.2–342.8; P=.009). These observations can be used to identify factors associated with mortality early in the course of severe respiratory failure in leptospirosis.

Journal Article.  1147 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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