Journal Article

<i>Mycobacterium kansasii</i> Septic Arthritis: French Retrospective Study of 5 Years and Review

L. Bernard, V. Vincent, O. Lortholary, L. Raskine, C. Vettier, D. Colaitis, D. Mechali, F. Bricaire, E. Bouvet, F. Bani Sadr, V. Lalande and C. Perronne

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 6, pages 1455-1460
Published in print December 1999 | ISSN: 1058-4838
Published online December 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313519
Mycobacterium kansasii Septic Arthritis: French Retrospective Study of 5 Years and Review

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Septic arthritis due to Mycobacterium kansasii is rare; only 40 cases have been published. A French national inquiry revealed the occurrence of 10 new cases between 1992 and 1997 (8 men and 2 women: mean age, 37 years; range, 25–54 years). Seven had an underlying condition: AIDS (n =4), chronic skin psoriasis and AIDS (n = 2), or a renal transplant (n = 1). Trauma to the joint, use of intra-articular corticosteroid(s) 1 month to 2 years after the event, and chronic skin psoriasis were risk factors. The mean interval between appearance of the first symptoms of arthritis and the diagnosis was 5 months. Monarthritis was localized to the knee (n = 4), wrist (n = 3), finger (n = 1), elbow (n = 1), or ankle (n = 1). The main diagnostic procedure was culture of a synovial biopsy specimen. In all cases, debridement was associated with antimycobacterial treatment. Three patients died of AIDS during treatment, and another is still undergoing treatment; the other 6 patients were cured. M. kansasii infection should be considered in all cases of indolent arthritis with any of the following risk factors: local trauma, local or systemic corticosteroid therapy, chronic skin psoriasis, and immunodepression, especially that due to human immunodeficiency virus infection.

Journal Article.  2954 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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