Journal Article

Outbreak of <i>Stenotrophomonas maltophilia</i> Bacteremia in Allogenic Bone Marrow Transplant Patients: Role of Severe Neutropenia and Mucositis

Jaime A. Labarca, Amy L. Leber, Valerie L. Kern, Mary C. Territo, Liliana E. Brankovic, David A. Bruckner and David A. Pegues

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 1, pages 195-197
Published in print January 2000 | ISSN: 1058-4838
Published online January 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313591
Outbreak of Stenotrophomonas maltophilia Bacteremia in Allogenic Bone Marrow Transplant Patients: Role of Severe Neutropenia and Mucositis

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From March 1997 through November 1997, 8 allogenic bone marrow transplant (BMT) patients developed Stenotrophomonas maltophilia bacteremia on the hematology service at UCLA Medical Center (Los Angeles). Five of these patients had undergone transplantation during the same hospitalization that S. maltophilia bacteremia was detected (case patients). Compared with 7 concurrently hospitalized allogenic BMT patients (control patients), the 5 case patients were more likely to have been hospitalized in room A (P = .045), to have severe neutropenia on the culture date (P = .028), to have a longer duration of severe neutropenia (P = .05), to have severe mucositis (P = .028), and to have received total parenteral nutrition (P = .028). Pulsed-field gel electrophoresis revealed that 2 of 3 isolates from case patients hospitalized in room A were identical. In allogenic BMT patients, severe neutropenia and severe mucositis may promote infection with S. maltophilia by impairing host defenses.

Journal Article.  2176 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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