Journal Article

Recurrent Urinary Tract Infections in Postmenopausal Women

Raul Raz, Yoshua Gennesin, Joseph Wasser, Zmira Stoler, Sophia Rosenfeld, Elimelech Rottensterich and Walter E. Stamm

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 1, pages 152-156
Published in print January 2000 | ISSN: 1058-4838
Published online January 2000 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/313596
Recurrent Urinary Tract Infections in Postmenopausal Women

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To evaluate factors associated with recurrent urinary tract infection (UTI) in postmenopausal women, we conducted a case-control study comparing 149 postmenopausal women referred to an infectious diseases outpatient clinic who had a history of recurrent UTI (case patients) with 53 age-matched women without a history of UTI (control patients). Each woman completed a questionnaire providing demographic data, history and clinical characteristics of prior infections, and information regarding risk factors for UTI. In addition, each patient underwent a gynecologic evaluation, renal ultrasound and urine flow studies, and blood group and secretor status testing. Three urologic factors—namely, incontinence (41% of case patients vs. 9.0% of control patients; P < .001), presence of a cystocele (19% vs. 0%; P < .001), and postvoiding residual urine (28% vs. 2.0%; P = .00008)—were all strongly associated with recurrent UTI. Multivariate analysis showed that urinary incontinence (odds ratio [OR], 5.79; 95% confidence interval [CI], 2.05–16.42; P = .0009), a history of UTI before menopause (OR, 4.85; 95% CI, 1.7–13.84; P = .003), and nonsecretor status (OR, 2.9; 95% CI, 1.28–6.25; P = .005) were most strongly associated with recurrent UTI in postmenopausal women. Prospective studies are needed to confirm these observations and to develop approaches for prevention.

Journal Article.  3707 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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