Journal Article

<i>Haemophilus influenzae</i> Pneumonia in Human Immunodeficiency Virus-Infected Patients

Elisa Cordero, Jerónimo Pachón, Antonio Rivero, José A. Girón, Jesús Gómez-Mateos, María D. Merino, Manuel Torres-Tortosa, Mercedes González-Serrano, Luis Aliaga, Antonio Collado, José Hernández-Quero, Antonio Barrera and Enrique Nuño

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 3, pages 461-465
Published in print March 2000 | ISSN: 1058-4838
Published online March 2000 | e-ISSN: 1537-6591 | DOI:
Haemophilus influenzae Pneumonia in Human Immunodeficiency Virus-Infected Patients

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Although Haemophilus influenzae is a common etiologic agent of pneumonia in patients infected with human immunodeficiency virus (HIV), the characteristics of this pneumonia have not been adequately assessed. We have prospectively studied features of H. influenzae pneumonia in 26 consecutive HIV-infected inpatients. Most of these patients were severely immunosuppressed; 73.1% had a CD4+ cell count <100/µL. A subacute clinical presentation was observed in 27% of the patients and was associated with a higher degree of immunosuppression (P=.04). Bilateral lung infiltrates were noted radiographically in 57.7% of the cases. The mortality attributable to H. influenzae pneumonia was 11.5%. Thus, pneumonia caused by H. influenzae affects mainly patients with advanced HIV disease, and since its clinical and radiological features may be diverse, this etiology should be considered when pneumonia occurs in patients with advanced HIV infection. The mortality rate associated with H. influenzae pneumonia is not higher than that occurring in the general population.

Journal Article.  3647 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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