Journal Article

Association Between Resistance to Vancomycin and Death in Cases of <i>Enterococcus faecium</i> Bacteremia

Jane M. Garbutt, Madhuri Ventrapragada, Benjamin Littenberg and Linda M. Mundy

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 3, pages 466-472
Published in print March 2000 | ISSN: 1058-4838
Published online March 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313694
Association Between Resistance to Vancomycin and Death in Cases of Enterococcus faecium Bacteremia

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We conducted a retrospective cohort study to determine the association between resistance to vancomycin and mortality among hospitalized patients with Enterococcus faecium bacteremia. We compared outcomes for patients infected with vancomycin-resistant versus vancomycin-susceptible E. faecium among 69 patients with bacteremia defined according to the National Nosocomial Infections Surveillance system. The univariate odds ratio (OR) for death associated with vancomycin resistance was 2.1 (P = .172). After controlling for severity of illness, we found that vancomycin resistance was not associated with mortality (OR, 1.74; 95% confidence interval, 0.5–6.12; P = .39). Vancomycin resistance does not independently increase mortality among patients with E. faecium bacteremia.

Journal Article.  4653 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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