Journal Article

GB Virus C/Hepatitis G Virus Infection Is Frequent in American Children and Young Adults

Atsushi Handa, Rima F. Jubran, Bruce Dickstein, Arianne Boylan, Naomi L. C. Luban, Neal S. Young and Kevin E. Brown

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 3, pages 569-571
Published in print March 2000 | ISSN: 1058-4838
Published online March 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313702
GB Virus C/Hepatitis G Virus Infection Is Frequent in American Children and Young Adults

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The novel flavivirus GB virus C/hepatitis G virus (GBV-C/HGV) has been detected in ∼2% of blood donors in the United States, and neutralizing antibody to the envelope protein (E2), a marker of previous infection with GBV-C/HGV, is present in ∼9% of donors. The rate of GBV-C/HGV infection among American children is unknown. To determine whether viral infection might occur during childhood, 160 serum specimens (obtained from blood bank samples) from children and young adults with no history of transfusion were tested. Viral RNA and antibody to E2 were detected in 6.3% and 9.4% of subjects, respectively. Evidence of previous or current infection (viremia and/or antibody to E2) was detected in 13.8% of subjects, indicating that GBV-C/HGV infection appears to be common among American children and young adults, even in the absence of blood transfusion.

Journal Article.  1611 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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