Journal Article

Detection of Epstein-Barr Virus in Posttransplantation T Cell Lymphoma in a Kidney Transplant Recipient: Case Report and Review

Carolina Frías, Ricardo Lauzurica, Manuel Vaquero and Josep Ma Ribera

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 3, pages 576-578
Published in print March 2000 | ISSN: 1058-4838
Published online March 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313704
Detection of Epstein-Barr Virus in Posttransplantation T Cell Lymphoma in a Kidney Transplant Recipient: Case Report and Review

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Posttransplantation T cell lymphomas (PTTLs) are rather unusual, and their etiology remains unclear. We describe a case of Epstein-Barr virus (EBV)-associated small bowel T cell lymphoma in a patient 5 years after kidney transplantation. EBV was detected in a biopsy sample by in situ hybridization, immunohistochemical staining, and polymerase chain reaction analysis. Eight previously reported cases of EBV-associated PTTL are reviewed, paying special attention to the methods used for assessing EBV. We believe that our case of EBV-associated PTTL is the most completely studied from the point of view of the methods used for detection of EBV. The prognosis of PTTL is poor, but it has been reported that therapeutic approaches can be successful if they are given early in the course of the illness. Therefore, it is necessary to improve the diagnosis PTTL and to assess the precise involvement of EBV in posttransplantation lymphoproliferative disorders.

Journal Article.  1479 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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