Journal Article

Interferon-α and Ribavirin Treatment of Hepatitis C in Children with Malignancy in Remission

Bertil Christensson, Thomas Wiebe, Ann Åkesson and Anders Widell

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 3, pages 585-586
Published in print March 2000 | ISSN: 1058-4838
Published online March 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313709
Interferon-α and Ribavirin Treatment of Hepatitis C in Children with Malignancy in Remission

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Twenty-eight cases of hepatitis C virus (HCV) infection were identified in children in a pediatric oncology ward during 2 nosocomial outbreaks. HCV infection spontaneously cleared in 6 patients (21%). Eleven patients with persistent HCV viremia who had malignant diseases in remission after treatment were given a 48-week course of combined therapy with interferon-α (5 × 106 U 3 times weekly) and oral ribavirin (15 mg/kg/d). Seven (64%) of the 11 patients had sustained virological responses 6 and 12 months after cessation of therapy. Side effects were common but generally were mild or moderate.

Journal Article.  1271 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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