Journal Article

Fulminant Meningococcal Septicemia: Dissociation between Plasma Thrombopoietin Levels and Platelet Counts

Anna Bjerre, Reidun Øvstebø, Peter Kierulf, Sverre Halvorsen and Petter Brandtzæg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 4, pages 643-647
Published in print April 2000 | ISSN: 1058-4838
Published online April 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313754
Fulminant Meningococcal Septicemia: Dissociation between Plasma Thrombopoietin Levels and Platelet Counts

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Thrombopoietin (TPO), interleukin (IL)-6, and platelets were measured serially in 9 patients with fulminant meningococcal septicemia and consumption coagulopathy. The results were compared with those of patients with meningococcal meningitis and mild meningococcemia (n = 10) and with those of healthy control subjects (n = 19). TPO levels in control subjects were below the detection limit (<63 pg/mL). In patients with fulminant meningococcal septicemia, the median TPO level on admission was 193 pg/mL (range, 133–401 pg/mL), and the level peaked within 3–7 days (median, 488 pg/mL; range, 239–1334 pg/mL). Platelet counts remained low, despite the elevated TPO levels. In patients with meningitis or meningococcemia, the median TPO level on admission was 112 pg/mL (range, <63–695 pg/mL), and the TPO level was not detectable within 48 h. Platelet counts for these patients remained within normal limits. Maximum IL-6 levels in patients with septicemia were observed on admission (median, 5317 pg/mL; range, 188–651,000 pg/mL) and increased earlier than TPO levels. In patients with fulminant septicemia, TPO level increases significantly whereas the level of circulating platelets does not.

Journal Article.  2737 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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