Journal Article

Bronchopulmonary and Mediastinal Leishmaniasis: An Unusual Clinical Presentation of <i>Leishmania donovani</i> Infection

Ben G. Marshall, Pascale Kropf, Kate Murray, Colin Clark, Adrienne M. Flanagan, Robert N. Davidson, Rory J. Shaw and Ingrid Müller

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 5, pages 764-769
Published in print May 2000 | ISSN: 1058-4838
Published online May 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313763
Bronchopulmonary and Mediastinal Leishmaniasis: An Unusual Clinical Presentation of Leishmania donovani Infection

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We describe a case of unusual leishmaniasis in a Sudanese man with a history of progressively enlarging granulomatous mediastinal lymphadenopathy, worsening hemoptysis, and an intense mucosal granulomatous inflammatory response in the large bronchi. Leishmania donovani DNA was detected in bronchial biopsies by polymerase chain reaction. This is a novel description of human leishmanial infection in an immunocompetent patient involving this anatomical site. The patient's condition improved clinically, spirometrically, and radiologically after a course of treatment with amphotericin B. The cell-mediated immune response was analyzed before, during, and after successful antileishmanial chemotherapy.

Journal Article.  2966 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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