Journal Article

Enteropathogens in Adult Patients with Diarrhea and Healthy Control Subjects: A 1-Year Prospective Study in a Swedish Clinic for Infectious Diseases

Bo Svenungsson, Åsa Lagergren, Erik Ekwall, Birgitta Evengård, Kjell Olof Hedlund, Anders Kärnell, Sven Löfdahl, Lennart Svensson and Andrej Weintraub

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue 5, pages 770-778
Published in print May 2000 | ISSN: 1058-4838
Published online May 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313770
Enteropathogens in Adult Patients with Diarrhea and Healthy Control Subjects: A 1-Year Prospective Study in a Swedish Clinic for Infectious Diseases

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A 1-year prospective study was conducted to identify enteropathogens in adults with diarrhea (n = 851) and in healthy control subjects (n = 203) by use of conventional laboratory methods. Virulence factor genes for diarrheagenic Escherichia coli were detected by polymerase chain reaction. Enteropathogens were identified in 56% of patients and 16% of control subjects. The isolation rate was 65% for patients with symptoms for <1 week and for travelers; >1 pathogen was found in 11% of patients. The most frequent enteropathogens were Campylobacter (13% of patients), Clostridium difficile (13%), enterotoxigenic Escherichia coli (8%), Salmonella (7%), Shigella (4%), Blastocystis hominis (4%), calicivirus (3%), rotavirus (3%), enteroaggregative E. coli (2%), Aeromonas (2%), Giardia intestinalis (2%), Cryptosporidium (2%), and astrovirus (2%). Less frequently isolated (≤1% of patients) were verotoxigenic E. coli, enteropathogenic E. coli, enteroinvasive E. coli, Entamoeba histolytica/Entamoeba dispar, microsporidia, and adenovirus. Fifty percent of the patients were hospitalized, and 43% needed intravenous fluids. The median duration of diarrhea was 14 days. Clinical features were not helpful for predicting the etiology of diarrhea.

Journal Article.  5789 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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