Journal Article

Veterinary Tuberculosis Vaccine Development

J. Frank T. Griffin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue Supplement_3, pages S223-S228
Published in print June 2000 | ISSN: 1058-4838
Published online June 2000 | e-ISSN: 1537-6591 | DOI:
Veterinary Tuberculosis Vaccine Development

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Tuberculosis caused by Mycobacterium bovis in domestic livestock and wildlife is a significant problem in many countries worldwide. Wildlife reservoirs of tuberculosis confound programs for tuberculosis eradication from domestic livestock. Successful vaccination against tuberculosis in domestic animals or wildlife could contribute to tuberculosis eradication. Bacille Calmette-Guérin (BCG) has been used as the prototype vaccine for domestic livestock and wildlife. The majority of studies have been carried out with BCG-vaccinated animals challenged experimentally with M. bovis. Although protection against disease has been evident in all these studies, protection against infection has rarely occurred. Results obtained with BCG vaccination of cattle, deer, ferrets, opossums, and rabbits are presented here and highlight the need for appropriate animal models for vaccination and control of the variables that influence the efficacy of BCG vaccine. Refinement of the existing animal models is essential for the advancement of tuberculosis vaccine research of relevance to animals and humans.

Journal Article.  4149 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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