Journal Article

Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis Vaccine

George W. Comstock

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue Supplement_3, pages S250-S253
Published in print June 2000 | ISSN: 1058-4838
Published online June 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313870
Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis Vaccine

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There is strong evidence that tuberculin sensitivity cannot be used to evaluate the efficacy of different strains of bacille Calmette-Guérin (BCG). For identifying efficacious strains of BCG and evaluating candidates for new vaccines, the best method is a randomized trial. Simple trials in which newborns would be vaccinated with new and old vaccines in alternate years could demonstrate which vaccine was the better.

Journal Article.  2381 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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