Journal Article

Safety and Immunogenicity of a Five-Dose Series of Inactivated <i>Mycobacterium vaccae</i> Vaccination for the Prevention of HIV-Associated Tuberculosis

Richard D. Waddell, Chifumbe Chintu, A. David Lein, Alimuddin Zumla, Margaret R. Karagas, K. S. Baboo, J. Dik F. Habbema, Anna N. A. Tosteson, Paul Morin, Susan Tvaroha, Robert D. Arbeit, Alwyn Mwinga and C. Fordham von Reyn

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue Supplement_3, pages S309-S315
Published in print June 2000 | ISSN: 1058-4838
Published online June 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313880
Safety and Immunogenicity of a Five-Dose Series of Inactivated Mycobacterium vaccae Vaccination for the Prevention of HIV-Associated Tuberculosis

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Five doses of inactivated Mycobacterium vaccae vaccine were administered intradermally to 22 human immunodeficiency virus (HIV)—infected patients (11 bacille Calmette-Guérin [BCG]—positive and 11 BCG-negative) in Zambia whose CD4 lymphocyte counts were ≥200 cells/mm3. HIV viral load and lymphocyte proliferation responses were compared for vaccine recipients and 22 HIV-infected control patients (11 BCG-positive and 11 BCG-negative). Immunization was safe and well tolerated in all patients, and induration at the vaccine site decreased from dose 1 to dose 5. A transient decrease in HIV viral load was observed in BCG-positive vaccine recipients after dose 3 but not after subsequent doses. Median lymphocyte stimulation indices to M. vaccae were 6.0 in vaccine recipients and 2.3 in control patients (P < .001). Stimulation indices were ≥3.0 in 19 vaccine recipients (86%) and 7 control patients (32%; P = .001). A 5-dose series of vaccination with inactivated M. vaccae is safe in HIV-infected patients and induces lymphocyte proliferation responses to the vaccine antigen. M. vaccae vaccine is a candidate for the prevention of tuberculosis in HIV infection.

Journal Article.  4718 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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