Journal Article

Potential Impact of Tuberculosis Vaccines as Epidemic Control Agents

T. Lietman and S. M. Blower

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 30, issue Supplement_3, pages S316-S322
Published in print June 2000 | ISSN: 1058-4838
Published online June 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313881
Potential Impact of Tuberculosis Vaccines as Epidemic Control Agents

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

We use 2 simple mathematical models (one a preexposure vaccine model and the other a postexposure vaccine model) to provide general insight into the effects of vaccination on tuberculosis epidemics. We discuss how these models can be used as health policy tools: to identify which vaccines are “equivalent,” to design control strategies, and to predict the epi-demiological impact of different vaccination strategies. Our results show that even moderately effective vaccines could have a significant effect on reducing tuberculosis epidemics if they can be coupled with moderate to high treatment rates. We suggest that both preexposure and postexposure tuberculosis vaccines can be used to help eliminate tuberculosis in developing countries. In developed countries, only a preexposure vaccine (used in combination with a high level of treatment) would be necessary to eliminate tuberculosis.

Journal Article.  4710 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.