Journal Article

Assessment of the Relationship between Antimicrobial Usage and Susceptibility: Differences between the Hospital and Specific Patient-Care Areas

Roger L. White, Lawrence V. Friedrich, Linda B. Mihm and John A. Bosso

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 1, pages 16-23
Published in print July 2000 | ISSN: 1058-4838
Published online July 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313916
Assessment of the Relationship between Antimicrobial Usage and Susceptibility: Differences between the Hospital and Specific Patient-Care Areas

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Current evidence suggests that controlling antibiotic resistance requires the monitoring of both susceptibility trends and antimicrobial usage within specific patient-care areas of the hospital. To assess the differences between antimicrobial usage-versus-susceptibility relationships found in the hospital and those relationships found in specific patient-care areas, susceptibility and antimicrobial usage data collected over a 5-year period (1992–1996) at the Medical University of South Carolina were analyzed. For each area, the relationship between drug use and susceptibility was analyzed for 8 gram-negative organisms with respect to 19 different agents and for 3 staphylococci with respect to 10 agents with use of simple linear regression. The relationships found in the hospital had a poorer overall agreement with the relationships found in the intensive care units (ICUs; <20%) than they did with the relationships found in the non-ICUs (∼65%). Surveillance should include both susceptibility and drug usage patterns in individual areas within an institution.

Journal Article.  4896 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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